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Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) (CAT#: Gly-118LC)

This product is a mouse monoclonal antibody with glycoyslation site at in Fc region. The antibody 4D5 with enhanced ADCC specficfically binds to human HER-2 and can be potentially used in the treatment of breast cancer.

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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg
Normal Tissue
Figure 3 High expression in esophagus
Figure 3 High expression in esophagus

* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg
Figure 4 IHC staining of human rectum
Figure 4 IHC staining of human rectum
(Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg
Figure 5 IHC staining of human urinary bladder
Figure 5 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg
Figure 6 Kidney
Figure 6 Kidney
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg
Figure 7 Breast
Figure 7 Breast
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

Glyco-engineering

  • Glycosylation site
  • Fc region
  • Glycosylation Type
  • N-glycosylation
  • Activity
  • Enhanced ADCC

Specifications

  • Target
  • HER-2 (Human epidermal growth factor receptor 2)
  • Host Species
  • Mouse
  • Type
  • Mouse antibody
  • Specificity
  • Human
  • Clone
  • 4D5
  • Applications
  • ELISA

Target

  • Alternative Names
  • ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
  • Related Disease
  • Breast cancer

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Downloads

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Single-domain Antibody Intrabody Chimeric Antibody Immunotoxin scFv Fragment Antibody Humanized Antibody Human Antibody Mouse Antibody Fab Glycosylation Fc Glycosylation Deglycosylated Antibody (Non-glycosylated IgGs) Chicken IgY Antibody Blocking Antibody Rabbit Monoclonal Antibody Fab Fragment Antibody Recombinant Antibody ADCC Enhanced Antibody MHC Tetramer for Cancer
CAT Product Name Application Type
NABG-059 Recombinant Anti-Human ERBB2 VHH Single Domain Antibody IHC, FC, CA, FuncS Llama VHH
PNBL-066 Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-066) SPR Llama VHH
PNBL-067 Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-067) SPR Llama VHH
PNBL-069 Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-069) ELISA Llama VHH
TAB-032CT Anti-Human HER2/neu Therapeutic Single Domain Antibody WB Single domain antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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