Recombinant Anti-Human HTR7 Antibody scFv Fragment
CAT#: MOB-2993z-S(P)
Recombinant Mouse Antibody scFv Fragment is against Human HTR7, expressed in E. coli.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22708/628_F11_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73617/165203_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73617/165167_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73617/165167_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73617/165167_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Pachytene spermatocytes Staining: Medium Intensity: Strong Quantity: <25% Preleptotene spermatocytes Staining: Medium Intensity: Strong Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73617/165167_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73617/165167_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, hTERT-HME1, LHCN-M2, U-251 MG, U-87 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148680-HTR7
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Specifications
- Immunogen
- Human 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Human 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled
- Species Reactivity
- Human
- Applications
- Used for immunoassaytechniques such as: Enzyme-linked Immunosorbent Assay; Western blot; Functional Study
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
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Reliable for Neuroresearch
The Anti-Human HTR7 scFv Fragment has proven invaluable in our neurological research. Its small size offers enhanced tissue penetration, allowing us to achieve clear visualizations of the HTR7 receptor in various brain tissues. The specificity and sensitivity in detecting receptor changes have greatly contributed to our understanding of serotonin's role in neural signaling.
Excellent for ELISA
Utilizing this scFv in our ELISA setups has greatly improved our ability to quantify the HTR7 receptor across different samples. The precision of the binding profile is commendable, helping us achieve reproducible and reliable results. The durable nature of the antibody ensures consistent outcomes, facilitating longitudinal studies of receptor dynamics.
Consistent and Versatile
The versatility of this scFv antibody fragment allows its application across various techniques, from Western blotting to functional studies. It's reassuring to note the consistent performance across batches, which significantly enhances the productivity and reliability of our assays focusing on human serotonin receptors. A vital addition to any serotonin-related research endeavor.
Q&As
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What research applications can the Anti-Human HTR7 scFv Fragment be utilized for?
A: The Recombinant Anti-Human HTR7 scFv Fragment is primarily used in immunological assays such as ELISA and Western blotting to identify and quantify the presence of the human serotonin receptor 7 (HTR7). This receptor plays a role in various neuropsychiatric and gastrointestinal studies, helping researchers explore serotonin's effects on mood, cognition, and intestinal functions.
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Which diseases can be studied using this antibody?
A: The antibody targets the human 5-Hydroxytryptamine (Serotonin) Receptor 7, involved in neurological and psychiatric conditions such as depression, anxiety, and schizophrenia. By binding specifically to HTR7, researchers can study receptor expression changes in these disorders, enhancing the understanding of serotonin's impact on mental health and opening avenues for developing novel therapeutics.
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What are the primary targets and interactions of the HTR7 receptor?
A: HTR7 is a serotonin receptor coupled to adenylate cyclase, influencing the levels of cyclic AMP in cells. Its primary targets include various neural pathways where it regulates circadian rhythm, thermoregulation, mood, and learning. By interacting with G proteins, HTR7 moderates neurotransmitter release, making it a critical focus for understanding serotonin-mediated signaling.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "HTR7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2993z | Mouse Anti-HTR7 Recombinant Antibody (MOB-2993z) | FC, IHC, CyTOF | Mouse IgG2b |
| VS13-YC561 | Rabbit Anti-HTR7 Recombinant Antibody (VS13-YC561) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2993z-F(E) | Recombinant Anti-Human HTR7 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1711 | Rabbit Anti-HTR7 Recombinant Antibody (clone DS1711AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3356 | Anti-HTR7 Immunohistochemistry Kit | IHC |
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