Recombinant Mouse Anti-Human MTM1 Antibody
CAT#: MOB-0938MZ
This antibody is a recombinant mouse monoclonal antibody which specifically reacts with human MTM1.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules and cells in glomeruli.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/26608_A_7_5_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10665/26604_A_6_2_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/57_F11_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/56_F11_1_blue_red_green.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/26608_A_7_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/26608_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/26608_A_6_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10008/26608_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171100-MTM1
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Specifications
- Immunogen
- Recombinant fragment: MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT , corresponding to amino acids 1-100 of Human MTM1
- Host Species
- Mouse
- Type
- Mouse antibody
- Specificity
- Human MTM1
- Species Reactivity
- Human
- Applications
- IHC-P
Target
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Exceptional for IHC Applications
This antibody excels in immunohistochemistry applications, providing clear and specific staining in tissue samples. Its performance with paraffin-embedded sections has greatly advanced our understanding of MTM1 distribution in various tissues.
Valuable for Muscular Disorder Research
We've utilized this antibody to explore the role of MTM1 in muscular disorders. Its specificity has provided crucial insights into MTM1's pathological roles, aiding in the development of potential therapeutic strategies.
High Specificity and Sensitivity
The high specificity and sensitivity of this antibody ensure minimal background noise, allowing for precise detection and analysis of MTM1. This quality is essential for producing reliable, publishable data.
Q&As
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What research applications is the Recombinant Anti-Human MTM1 Antibody suitable for?
A: This antibody is particularly effective in Immunohistochemistry on paraffin-embedded sections (IHC-P). Its capability to specifically detect human MTM1 makes it invaluable for studies focusing on protein localization and tissue distribution.
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How does MTM1 impact muscular diseases?
A: MTM1 is known for its role in myotubular myopathy, a severe genetic disorder affecting muscle function. Understanding the expression and function of MTM1 can aid in developing therapeutic approaches for such muscular diseases.
-
In what diseases beyond muscular disorders could this antibody be used?
A: Apart from muscular disorders, MTM1's role in cellular homeostasis and signaling suggests possible applications in other diseases where these processes are affected, such as neurodegenerative disorders.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
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| NAB-1762-VHH | Recombinant Anti-Human MTM1 VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
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| MOB-3168z | Mouse Anti-MTM1 Recombinant Antibody (clone 36B2) | WB, IP, IF, IHC, ELISA | Mouse IgG2b, κ |
| HPAB-1014WJ | Human Anti-MTM1 Recombinant Antibody (HPAB-1014WJ) | IHC | Human IgG |
| CAT | Product Name | Application | Type |
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| HPAB-1014WJ-S(P) | Mouse Anti-MTM1 Recombinant Antibody; scFv Fragment (HPAB-1014WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-1014WJ-F(E) | Mouse Anti-MTM1 Recombinant Antibody; Fab Fragment (HPAB-1014WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
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| VS-0525-XY4567 | Anti-MTM1 Immunohistochemistry Kit | IHC |
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