Recombinant Anti-human MFGE8 Antibody scFv Fragment
CAT#: MOB-657-S(P)
Recombinant Mouse Antibody scFv Fragment is capable of binding to Human MFGE8, expressed in E. coli.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2807/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2807/8016_A_1_7_selected.jpg
Normal Tissue
Figure 3 IHC staining of human endometrium
High expression. RNA expression: 444.7 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2753/7591_B_5_3_val_selected.jpg
Normal Tissue
Figure 4 IHC staining of human duodenum
Low expression. RNA expression: 21.2 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2753/7591_A_9_2_val_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Glial cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2807/8042_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Enterocytes - Microvilli
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2753/7591_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2753/7591_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2753/7591_A_7_5.jpg
Normal Tissue
Figure 9 Testis
Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2807/8016_A_4_6.jpg
Normal Tissue
Figure 10 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2753/7591_A_7_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000140545-MFGE8
❮
❯
Specifications
- Immunogen
- Human milk fat globule-EGF factor 8 protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Human milk fat globule-EGF factor 8 protein
- Species Reactivity
- Human
- Applications
- Can be useful in applications such as: Western blot; Flow Cytometry; Functional Study
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- MFGE8; milk fat globule-EGF factor 8 protein; BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888; lactadherin; medin; sperm surface protein hP47; sperm associated antigen 10; breast epithelial antigen BA46; O-acetyl disialoganglioside
- Gene ID
- 4240
- UniProt ID
- Q08431
REVIEWS AND Q&AS
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Effective for Functional Studies
This antibody fragment has provided exceptional clarity in our functional analyses, specifically enhancing our ability to monitor protein interactions. Its performance in flow cytometry was particularly enlightening, revealing detailed insights into cellular behavior that underpin our research strategies.
Reliable for Western Blot
We've extensively used this scFv fragment for Western blotting. Its specificity and sensitivity are top-notch, ensuring that our protein quantification efforts are accurate and reproducible. This reliability boosts our confidence in the data generated from our experiments.
Enhances Cellular Mechanism Studies
The antibody excels in exploring cellular mechanisms, especially concerning immune responses. We've gained new insights into phagocytosis and related processes, which are critical in advancing our understanding of immune regulation.
Q&As
-
What research applications is the Recombinant Anti-human MFGE8 Antibody scFv Fragment suitable for?
A: This scFv fragment is well-suited for Western blot and flow cytometry applications. Researchers employ it for functional studies due to its ability to specifically bind to the human milk fat globule-EGF factor 8 protein (MFGE8), thereby facilitating investigations into cellular processes and protein interactions.
-
How does MFGE8 influence disease mechanisms?
A: MFGE8 is involved in processes such as phagocytosis and cell adhesion. Abnormal MFGE8 expression can contribute to autoimmune diseases and cancer progression, making this antibody a vital tool in studying these pathologies and potentially developing targeted treatments.
-
In what diseases beyond cancer could this antibody be used?
A: Apart from cancer, the antibody is applicable in studies on autoimmune diseases where MFGE8 may play a role in disease progression, offering opportunities to explore new therapeutic interventions.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-657-F(E) | Recombinant Anti-human MFGE8 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| MHH-657-F(E) | Recombinant Human Anti-human MFGE8 Antibody Fab Fragment | WB, ELISA, IHC, FuncS | Fab |
| FAMAB-0365JF-F(E) | Mouse Anti-MFGE8 Recombinant Antibody (clone 3D10); Fab Fragment | IB, WB, ELISA, FuncS | Mouse Fab |
| HPAB-2103-FY-F(E) | Human Anti-MFGE8 Recombinant Antibody (clone HuHMFG1); Fab Fragment | IA | Humanized Fab |
| HPAB-2104-FY-F(E) | Mouse Anti-MFGE8 Recombinant Antibody (clone HMFG1); Fab Fragment | IA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-657 | Recombinant Human Anti-human MFGE8 Antibody | IF, ELISA, FuncS | IgG |
| MOB-1240MZ | Recombinant Mouse Anti-Human MFGE8 Antibody (clone FEN56), Biotin-Conjugated | ICC, IF, IHC-P, IP, WB | Mouse antibody |
| FAMAB-0225CQ | Mouse Anti-MFGE8 Recombinant Antibody (clone Mc3) | ELISA, IF, Block, FuncS | Mouse IgG1, κ |
| HPAB-2104-FY | Mouse Anti-MFGE8 Recombinant Antibody (clone HMFG1) | IA | Mouse IgG |
| ZG-0144U | Mouse Anti-MFGE8 Recombinant Antibody (clone 2B2D10) | ELISA, IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-657-S(P) | Recombinant Human Anti-human MFGE8 Antibody scFv Fragment | WB, IP, FuncS | scFv |
| FAMAB-0225CQ-S(P) | Mouse Anti-MFGE8 Recombinant Antibody (clone Mc3); scFv Fragment | ELISA, IF, FuncS | Mouse scFv |
| FAMAB-0365JF-S(P) | Mouse Anti-MFGE8 Recombinant Antibody (clone 3D10); scFv Fragment | IB, WB, ELISA, FuncS | Mouse scFv |
| HPAB-2103-FY-S(P) | Human Anti-MFGE8 Recombinant Antibody (clone HuHMFG1); scFv Fragment | IA | Humanized scFv |
| HPAB-2104-FY-S(P) | Mouse Anti-MFGE8 Recombinant Antibody (clone HMFG1); scFv Fragment | IA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0763CL-F(E) | Mouse Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0763CL-F(E)) | ELISA | Mouse Fab |
| TAB-0764CL-F(E) | Mouse Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0764CL-F(E)) | ELISA | Mouse Fab |
| TAB-0765CL-F(E) | Mouse Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0765CL-F(E)) | ELISA | Mouse Fab |
| TAB-0766CL-F(E) | Mouse Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0766CL-F(E)) | ELISA | Mouse Fab |
| TAB-0767CL-F(E) | Mouse Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0767CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0768CL-F(E) | Human Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0768CL-F(E)) | ELISA | Humanized Fab |
| TAB-0769CL-F(E) | Human Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0769CL-F(E)) | ELISA | Humanized Fab |
| TAB-0770CL-F(E) | Human Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0770CL-F(E)) | ELISA | Humanized Fab |
| TAB-0771CL-F(E) | Human Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0771CL-F(E)) | ELISA | Humanized Fab |
| TAB-0772CL-F(E) | Human Anti-MFGE8 Recombinant Antibody; Fab Fragment (TAB-0772CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC048 | PE-A*02:01/Human BA46 (GLQHWVPEL) MHC Tetramer | FCM | |
| MHC-LC049 | APC-A*02:01/Human BA46 (GLQHWVPEL) MHC Tetramer | FCM | |
| MHC-LC050 | BV421-A*02:01/Human BA46 (GLQHWVPEL) MHC Tetramer | FCM | |
| MHC-YF323 | A*02:01/Human BA46 (NLFETPVEA) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0365JF | Mouse Anti-MFGE8 Recombinant Antibody (clone 3D10) | WB, ELISA, IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4370 | Anti-MFGE8 Immunohistochemistry Kit | IHC |
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