Recombinant Human Anti-Human MBD4 Antibody Fab Fragment, clone D84 (CAT#: DrMAB-399)
Recombinant Human Antibody binds selectively to Human MBD4, expressed in E. coli.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/if_selected.jpg
Figure 2 IHC staining of human skin
(Immunohistochemical staining of human skin shows strong nuclear positivity in epidermal cells and adnexal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/ihc_selected.jpg
(Immunohistochemical staining of human skin shows strong nuclear positivity in epidermal cells and adnexal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/36_A1_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/36_A1_1_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/37_A1_1_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/37_A1_1_red_green.jpg
Figure 5 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_B_8_5.jpg
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_B_8_5.jpg
Figure 6 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Preleptotene spermatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_A_4_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Preleptotene spermatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_A_4_6.jpg
Figure 7 Skin
(Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Langerhans
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_B_7_1.jpg
(Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Langerhans
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_B_7_1.jpg
Figure 8 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_A_8_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2031/8666_A_8_8.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000129071-MBD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000129071-MBD4
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Type
- Fab
- Specificity
- reacts with human MBD4
- Species Reactivity
- Human
- Clone
- D84
- Applications
- IP; IF; ELISA
Product Property
- Storage
- short term – store at 4°C (over 6 months), long term - PBS -20°C or -80°C
Target
- Alternative Names
- MBD4; methyl-CpG binding domain 4 DNA glycosylase; MED1; methyl-CpG-binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; methyl-CpG b
- Gene ID
- 8930
- UniProt ID
- O95243
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ106 | Mouse Anti-MBD4 Recombinant Antibody (VS3-CJ106) | WB, ELISA | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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