Recombinant Human Anti-MART1 Soluble TCR (scTCR-216CQ-S(P))
CAT#: scTCR-216CQ-S(P)
Recombinant Human single-chain TCR (scTCR) recognizes MART1 peptide (ELAGIGILTV) in the context of HLA-A2. The scTCR is responsible for the specificity of T cells.
Gene Expression
Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
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Specifications
- Host Species
- Human
- Target
- MART1
- Species Reactivity
- Human
- Epitope
- ELAGIGILTV
- MHC
- HLA-A2
- Type
- Single-Chain TCR
- Related Disease
- Melanoma
Target
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High Specificity For MART1
Our lab has been studying melanoma antigens, and this recombinant human TCR was perfect for our needs. It effectively recognized the MART1 peptide ELAGIGILTV when presented by HLA-A2, helping us validate our antigen presentation models.
Excellent Tool For TCR Research
We needed a reliable soluble TCR to investigate the specificity of T cells targeting the MLANA gene product. This scTCR performed well in our assays, providing consistent data regarding the recognition of MHC class I complexes.
Q&As
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What is the specific peptide sequence this TCR recognizes?
A: This recombinant human soluble TCR recognizes the MART1 peptide sequence ELAGIGILTV. It recognizes this peptide fragment, which usually consists of amino acids 27 to 35, in the context of the HLA-A2 MHC class I complex.
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Where are the complexes recognized by this TCR typically found?
A: The MHC class I complexes that present the MART1 peptide are typically found on the surface of melanoma cells. This TCR is responsible for the specificity of T cells targeting the MLANA gene product, also known as Melan-A.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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