Recombinant Mouse Antibody binds selectively to Mouse CD44.
Figure 1 CD44-expressing mesenchymal cells are found throughout newly formed fibrotic lung tissue obtained from patients who died from the fibroproliferative disorder of acute alveolar fibrosis after lung injury.
Lung tissue obtained immediately after death was snap frozen and immunostained with anti–CD44 monoclonal antibody.
Svee, K., White, J., Vaillant, P., Jessurun, J., Roongta, U., Krumwiede, M., ... & Henke, C. (1996). Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. The Journal of clinical investigation, 98(8), 1713-1727.
Figure 2 Identification of the 85-kD fibroblast CD44 isoform by Western analysis with anti–CD44 monoclonal antibodies.
Western analysis of undigested and chondroitinase-digested acute lung injury fibroblast lysates.
Svee, K., White, J., Vaillant, P., Jessurun, J., Roongta, U., Krumwiede, M., ... & Henke, C. (1996). Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. The Journal of clinical investigation, 98(8), 1713-1727.
Figure 3 Identification of the 85-kD fibroblast CD44 isoform by immunoprecipitation with anti–CD44 monoclonal antibodies.
Undigested and chondroitinase-digested Hermes 3 immunoprecipitated proteins from acute lung injury fibroblasts. Undigested and chondroitinase-digested proteins immunoprecipitated with monoclonal antibodies that only recognize the unsaturated bonds of either 4- or 6-sulfated chondroitin sulfate residues that remain attached to the core protein after chondroitinase digestion.
Svee, K., White, J., Vaillant, P., Jessurun, J., Roongta, U., Krumwiede, M., ... & Henke, C. (1996). Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. The Journal of clinical investigation, 98(8), 1713-1727.
Figure 4 Anti-CD44 antibody inhibits acute lung injury fibroblast invasion of a fibrin matrix.
Acute lung injury fibroblasts were allowed to attach and spread (4 h, 378C) on the surface of tissue culture wells. They were then overlayed with a fibrin gel and cultured in the presence of anti–CD44 monoclonal antibody in varying concentrations: 0.01 mg/ml, 1.0 mg/ml, 20 mg/ml, or an isotype IgG1 control monoclonal antibody.
Svee, K., White, J., Vaillant, P., Jessurun, J., Roongta, U., Krumwiede, M., ... & Henke, C. (1996). Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. The Journal of clinical investigation, 98(8), 1713-1727.
Figure 5 Fibroblast migration on the provisional matrix proteins fibronectin, fibrinogen are blocked by anti-CD44 antibody.
Acute lung injury fibroblasts were preincubated for 30 min with varying concentrations of antiCD44 antibody. Fibroblast migration to the undersides of filters coated with fibronectin was assessed using modified Boyden chambers in the presence of anti–CD44 antibody or IgG1 isotypematched control antibody.
Svee, K., White, J., Vaillant, P., Jessurun, J., Roongta, U., Krumwiede, M., ... & Henke, C. (1996). Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. The Journal of clinical investigation, 98(8), 1713-1727.
Figure 6 Illustrates the effect of anti-CD44 mAb on CD2 receptor-stimulated T cell proliferation.
Figure 7 Illustrates the effects of anti-CD44 mAb on IL-2 production by T cells stimulated with OKT3
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• High repeatability
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-727 | Anti-CD44 Recombinant Antibody (Bivatuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
TAB-236LC | Anti-Human CD44 Recombinant Antibody (huPTA-4621) | FuncS | Humanized antibody |
TAB-236LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) | FC | Humanized antibody |
TAB-236LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-226LC | Human Anti-CD44 Recombinant Antibody (TAB-226LC) | Cyt, ELISA, FC | Human IgG1, λ |
TAB-227LC | Anti-Human CD44 Recombinant Antibody (1A9.A6.B9) | Block, ELISA, FC | Human antibody |
TAB-228LC | Anti-Human CD44 Recombinant Antibody (2D1.A3.D12) | FC, ELISA | Human antibody |
TAB-239LC-S(P) | Human Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-239LC-S(P)) | FC | Human scFv |
TAB-239LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-239LC-F(E)) | FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-231LC | Human Anti-CD44 Recombinant Antibody (TAB-231LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-232LC | Human Anti-CD44 Recombinant Antibody (TAB-232LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-235LC | Anti-Human CD44 Recombinant Antibody (chPTA-4621) | FuncS | Chimeric antibody (mouse/human) |
TAB-231LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-231LC-S(P)) | ELISA | Mouse scFv |
TAB-232LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-232LC-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0101MZ | Chicken Anti-CD44 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-378CQ | Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1) | FC, IF, Inhib, IP, WB | Rat IgG2b |
NEUT-381CQ | Human Anti-CD44 Recombinant Antibody (clone Hermes-3) | ELISA, FC, IF, IHC, IP, Neut, WB | Human IgG1, κ |
NEUT-382CQ | Rat Anti-CD44 Recombinant Antibody (clone IM7) | Block | Rat IgG2b |
NEUT-383CQ | Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC | Block, FC, IP, WB, FuncS | Rat IgG1, κ |
NEUT-384CQ | Rat Anti-CD44 Recombinant Antibody (clone KM81) | IF, IHC-P, FC, Block | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-379CQ | Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG2a |
NEUT-380CQ | Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) | WB, Neut, ELISA, FC, IF, IHC, IP | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0563 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB) | FC, IF, IHC-Fr, IHC-P, WB | Rabbit IgG |
MOR-4548 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS) | IF, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0019-CN-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone AV6); scFv Fragment | FC | Mouse scFv |
HPAB-0746-FY-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0746-FY-F(E)) | ELISA | Human Fab |
HPAB-0747-FY-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0747-FY-F(E)) | ELISA | Human Fab |
HPAB-1055-FY-F(E) | Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1055-FY-F(E)) | IHC, Inhib, FC | Mouse Fab |
HPAB-1056-FY-F(E) | Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1056-FY-F(E)) | IHC, Inhib, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0154-FY | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1) | Inhib, WB | Humanized IgG1 |
HPAB-N0328-YC | Rat Anti-CD44 Recombinant Antibody (clone 9A4) | WB, ELISA, IHC-P, IHC-Fr | Rat IgG1 |
HPAB-0746-FY | Human Anti-CD44 Recombinant Antibody (HPAB-0746-FY) | ELISA | Human IgG |
HPAB-0747-FY | Human Anti-CD44 Recombinant Antibody (HPAB-0747-FY) | ELISA | Human IgG |
HPAB-0563-WJ | Human Anti-CD44 Recombinant Antibody (clone 1A9) | WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0154-FY-F(E) | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1); Fab Fragment | Inhib | Humanized Fab |
HPAB-1055-FY-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (HPAB-1055-FY-S(P)) | IHC, Inhib, FC | Mouse scFv |
HPAB-1056-FY-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (HPAB-1056-FY-S(P)) | IHC, Inhib, FC | Mouse scFv |
HPAB-0443-YJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone CA14); Fab Fragment | ELISA, FuncS | Human Fab |
HPAB-1173WJ-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1173WJ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-727 | Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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