Recombinant Rat Anti-Mouse Siglec1 Antibody, clone 3D6.112 (CAT#: DrMAB-106)
Recombinant Rat Antibody binds selectively to Rat Siglec1.
Specific Inquiry
FC
Figure 1 Flow cytometry analysis. Shadow areas indicate isotype control, dotted lines indicate Lv-shSiglec-1 and solid lines indicate Lv-shNC. Statistic results of Siglec-1 mean flfluorescence intensity (MFI) were shown.
Xiong, Y. S., Wu, A. L., Mu, D., Yu, J., Zeng, P., Sun, Y., & Xiong, J. (2017). Inhibition of siglec-1 by lentivirus mediated small interfering RNA attenuates atherogenesis in apoE-deficient mice. Clinical immunology, 174, 32-40.
IHC
Figure 2 At 22wk, Immunohistochemistry was used to examine Siglec-1 suppression in aortic plaques (×400), scale bars, 100 μm. Long arrows indicate Siglec-1(+) cells and arrowheads indicate Siglec-1(−) cells.
Xiong, Y. S., Wu, A. L., Mu, D., Yu, J., Zeng, P., Sun, Y., & Xiong, J. (2017). Inhibition of siglec-1 by lentivirus mediated small interfering RNA attenuates atherogenesis in apoE-deficient mice. Clinical immunology, 174, 32-40.
ELISA
Figure 3 Statistical analysis. n = 11 for each group and data showed mean ± SD.
Xiong, Y. S., Wu, A. L., Mu, D., Yu, J., Zeng, P., Sun, Y., & Xiong, J. (2017). Inhibition of siglec-1 by lentivirus mediated small interfering RNA attenuates atherogenesis in apoE-deficient mice. Clinical immunology, 174, 32-40.
Specifications
- Immunogen
- Spleen cells from AO rats immunised with thioglycollate-elicted mouse peritoneal macrophages (TPM) that had been cutured in mouse serum to induce sheep erythrocyte receptor (SER).
- Host Species
- Rat
- Type
- IgG
- Specificity
- This antibody specifically recognize mouse CD169, which is a 180-185-kDa member of the Siglec family of macrophage-specific cell adhesion and endocytic receptors interacting with sialylated glycans. This receptor is expressed on a subset of macrophages that are found with high frequency in the spleen, liver, lymph node, and bone marrow. CD169 can also be detected on monocytes in the bone marrow and periphery.
- Clone
- 3D6.112
- Applications
- FC, IHC, ELISA
Product Property
- Purification
- Protein A affinity purified
- Buffer
- PBS with preservative (0.02% Proclin 300)
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Applications
- Application Notes
- The Mouse Siglec1 antibody has been reported in applications of Flow Cytometry, Immunohistochemistry, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Siglec1; sialic acid binding Ig-like lectin 1, sialoadhesin; Sn; Cd169; Siglec-1; sialoadhesin; SER; sheep erythrocyte receptor; sialic acid-binding Ig-like lectin 1
- Gene ID
- 20612
- UniProt ID
- G3X8X6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1373CT | Recombinant Mouse anti-Human SIGLEC1 Monoclonal antibody (8-340) | FC | |
| HPAB-1762LY | Human Anti-SIGLEC1 Recombinant Antibody (clone CBL038) | FC, ELISA, Inhib | Humanized IgG |
| FAMAB-1630CQ | Rabbit Anti-SIGLEC1 Recombinant Antibody (clone SER-4) | IHC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1762LY-S(P) | Human Anti-SIGLEC1 Recombinant Antibody (clone CBL038); scfv Fragment | FC, ELISA, Inhib | Humanized scfv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1762LY-F(E) | Human Anti-SIGLEC1 Recombinant Antibody (clone CBL038); Fab Fragment | FC, ELISA, Inhib | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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