SPDB-DM4 (CAT#: ADCsR-046CL)

This set is made by DM4 conjugated to SPDB linker. DM4 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. SPDB, a disulfide linker, is extensively exploited as a chemically labile linkage.