Creative Biolabs provides custom scFv4-Ig design and construction services for therapeutic antibody engineering study. Our innovative scientists have developed powerful technique and method for generation of multispecific antibodies with satisfactory controllability and operability. We guarantee to offer the reliable and efficient services to meet our customer’s individual requirements.
Figure: Diagram of ScFv4-Ig
ScFv4-Ig, as one of the IgG-like molecules, is a multispecific antibody developed by fusing two scFvs to the CL domain and another two different scFvs to the first CH1 domain of the IgG heavy chain, or vice versa. With these constructs, a tetravalent and tetraspecific antibody (1 + 1 + 1 + 1 antigen-binding valency) can be obtained in vitro, which can be used for a therapeutic purposes for targeting two different receptors depending on their expression levels, activation status and downstream signal molecules of each receptor.
Together with our experienced researchers, Creative Biolabs is able to provide fast delivery and efficient service just for generating tetravalent and tetraspecific antibodies with the best targeting activity, which can be used for therapeutic purpose.
For research use only. Not intended for any clinical use.