Anti-Nectin-4 (T-14)-vc-MMAE ADC (CAT#: ADC-148LCT)

• Antibody Overview
• Human IgG (Abgenix XenoMouse transgenic Mouse)

• Clone
• T-14

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and-heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

• Alternative Names
• PVRL4; poliovirus receptor-related 4; LNIR; PRR4; EDSS1; nectin-4; nectin-4; nectin 4; Ig superfamily receptor LNIR; poliovirus receptor-related protein 4;

• Gene ID
• 81607

• UniProt ID
• K4PZ75

• ADC-149LCT
• Anti-Nectin-4 (T-14)-mc-vc-MMAE ADC

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