Anti-EFNA4 (clone huE47)-AcBut-CM ADC (CAT#: ADC-043CL)

• Antibody Overview
• EFNA4 Antibody huE47

• Clone
• huE47

• Linker
• AcBut (4-(4'acetylphenoxy)butanoic acid)

• Linker Class/Description
• Class: Chemically cleavable linkers-Acid-labile linkers
  Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

• Drug
• CM (N-acetyl-y-calicheamicin dimethyl hydrazide)

• Introduction
• This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]

• Alternative Names
• EFNA4; ephrin-A4; EFL4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4;

• Gene ID
• 1945

• UniProt ID
• P52798

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