Anti-ITGB3 (Tadocizumab)-RGD-MMAE-HAS ADC

CAT#: ADC-173LCT

This ADC product is composed of an anti-ITGB3 antibody (clone Tadocizumab) conjuagated via a RGD linker to MMAE-HAS (MF-T-RGD-MMAE-HAS). It has demonstrated a response in Solid malignancies treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.

Gene Expression
Figure 1 IF staining of human cell line U-251 MG Figure 2 IHC staining of human bone marrow Figure 3 Bone marrow Figure 4 RNA cell line category: Cell line enhanced (EFO-21, HEL, RPTEC TERT1, U-87 MG, WM-115)

Specifications

  • Antibody Overview
  • Tadocizumab is a Humanized monoclonal Antibody that acts on the cardiovascular system.It binds to integrin αIIbβ3, a fibrinogen and fibronectin receptor found on platelets.
  • Clone
  • Tadocizumab
  • Linker
  • RGD
  • Drug
  • MMAE-HAS
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; integrin beta-3; platelet membrane glycoprotein IIIa;
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