Anti-ITGB3 (Tadocizumab)-RGD-MMAE-HAS ADC
CAT#: ADC-173LCT
This ADC product is composed of an anti-ITGB3 antibody (clone Tadocizumab) conjuagated via a RGD linker to MMAE-HAS (MF-T-RGD-MMAE-HAS). It has demonstrated a response in Solid malignancies treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.




Specifications
- Antibody Overview
- Tadocizumab is a Humanized monoclonal Antibody that acts on the cardiovascular system.It binds to integrin αIIbβ3, a fibrinogen and fibronectin receptor found on platelets.
- Clone
- Tadocizumab
- Linker
- RGD
- Drug
- MMAE-HAS
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
- Alternative Names
- ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; integrin beta-3; platelet membrane glycoprotein IIIa;
- Gene ID
- 3690
- UniProt ID
- P05106
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Datasheet
MSDS
COA
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-785-sdAb | Recombinant Anti-human ITGB3 VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-109-F(E) | Anti-Human Integrin lpha 2b beta 3 Recombinant Antibody Fab Fragment (Tadocizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Fab - G1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-251 | Mouse Anti-ITGB3 Recombinant Antibody (clone 314.1); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
PSBW-083 | Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2); scFv Fragment | Block | Mouse scFv |
HPAB-0030-YJ-S(P) | Mouse Anti-ITGB3 Recombinant Antibody (clone SZ-21); scFv Fragment | WB, ELISA, FC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-251 | Mouse Anti-ITGB3 Recombinant Antibody (clone 314.1); Fab Fragment | WB, ELISA, IF, FuncS | Mouse Fab |
PFBW-083 | Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2); Fab Fragment | Block | Mouse Fab |
HPAB-0030-YJ-F(E) | Mouse Anti-ITGB3 Recombinant Antibody (clone SZ-21); Fab Fragment | WB, ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABW-083 | Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2) | Block | Mouse IgG |
MRO-1979-CN | Rabbit Anti-ITGB3 Polyclonal Antibody (MRO-1979-CN) | WB, IHC, FC | Rabbit IgG |
MRO-1980-CN | Rabbit Anti-ITGB3 Polyclonal Antibody (MRO-1980-CN) | WB, IHC, IF | Rabbit IgG |
HPAB-0030-YJ | Mouse Anti-ITGB3 Recombinant Antibody (clone SZ-21) | WB, ELISA, FC | Mouse IgG |
VS3-CJ394 | Mouse Anti-ITGB3 Recombinant Antibody (clone PT0052) | IHC-P | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0577CL | Human Anti-ITGB3 Recombinant Antibody (TAB-0577CL) | WB, IF, ELISA | Human IgG |
TAB-0577CL-S(P) | Human Anti-ITGB3 Recombinant Antibody; scFv Fragment (TAB-0577CL-S(P)) | ELISA | Human scFv |
TAB-0577CL-F(E) | Human Anti-ITGB3 Recombinant Antibody; Fab Fragment (TAB-0577CL-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0299MZ | Chicken Anti-ITGB3 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
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MHC-LC1370 | PE-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer | FCM | |
MHC-LC1371 | APC-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer | FCM | |
MHC-LC1372 | BV421-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1598CQ | Recombinant Mouse Anti-ITGB3 Antibody (25E11) | FC, IF, Inhib | IgM, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1599CQ | Recombinant Armenian Hamster Anti-Itgb3 Antibody (2C9.G2(HMß3-1)) | FC, BL, Activ, IHC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1600CQ | Recombinant Armenian hamster Anti-Itgb3 Antibody (2C9.G3) | FC, FuncS, Neut, IF | IgG |
NEUT-1601CQ | Recombinant Mouse Anti-ITGB3 Antibody (PM6/13) | WB, Neut, ELISA, FC, ICC, IF, IHC, IHC-Fr, IHC-P, IP, ICC | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1885 | Hi-Affi™ Recombinant Rabbit Anti-ITGB3 Monoclonal Antibody (DS1885AB) | ICC, IF, IHC-P, WB, IHC-Fr | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-1009LC | Recombinant Mouse Anti-ITGB3 Antibody (1E6) | FC | IgG |
EPAF-1010LC | Recombinant Mouse Anti-ITGB3 Antibody (7E3) | FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC54 | Mouse Anti-ITGB3 Recombinant Antibody (VS-0924-YC54) - Cancer Stem Cell Marker | IHC, WB | Mouse IgG1 |
VS-0924-YC55 | Rabbit Anti-ITGB3 Antibody (VS-0924-YC55) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-1024-XY105 | Mouse Anti-NHP ITGB3 Recombinant Antibody (clone VIPL2) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-XY1157 | Anti-ITGB3 Immunohistochemistry Kit | IHC | |
VS-0525-XY3660 | Anti-Mouse ITGB3 Immunohistochemistry Kit | IHC | |
VS-0525-XY3659 | Anti-Human ITGB3 Immunohistochemistry Kit | IHC | |
VS-0525-XY3661 | Anti-Rat ITGB3 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC671 | Recombinant Anti-ITGB3 Vesicular Antibody, EV Displayed (VS-0425-YC671) | ELISA, FC, Cell-uptake |
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