Anti-HER2 (Trastuzumab)-AO-MC-PEG8-Dol10 (Glyco Dol10) ADC (CAT#: ADC-102LCT)

• Antibody Overview
• Humanized (from Mouse) Anti-HER2

• Clone
• Trastuzumab

• Linker
• AO-Mc-PEG8

• Linker Class/Description
• Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• Dol10 (Thiol Dol10)

• Introduction
• This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

• Alternative Names
• ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

• Gene ID
• 2064

• UniProt ID
• P04626

• ADC-132LCT
• Anti-HER2 (trastuzumab)-hydroxyl amino PEG linker-MMAD (monomethyl auristatin D) ADC

• ADC-133LCT
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• ADC-101LCT
• Anti-HER2 (Trastuzumab)-MC-PEG8-Dol10 (Thiol Dol10) ADC

• ADC-134LCT
• Anti-HER2 (trastuzumab)-SPDP-DM1 ADC

• ADC-103LCT
• Anti-HER2 (Trastuzumab)-MC-MMAE (Thiol MMAE) ADC

• ADC-135LCT
• Anti-HER2 (trastuzumab)-SPP-DM1 ADC

• ADC-104LCT
• Anti-HER2 (Trastuzumab)-AO-MC-MMAE (Glyco MMAE) ADC

• ADC-136LCT
• Anti-HER2 (trastuzumab)-SSNPP-DM3 ADC

• ADC-137LCT
• Anti-HER2 (trastuzumab)-SSNPP-DM4 ADC

• ADC-123LCT
• Anti-HER2 (trastuzumab)-bisAlk-vc-MMAE ADC

• ADC-138LCT
• Anti-HER2 (trastuzumab)-auristatin ADC

• ADC-126LCT
• Anti-HER2 (Trastuzumab)-CC-MMAD ADC

• ADC-127LCT
• Anti-HER2 (Trastuzumab)-mc-MMAD ADC

• ADC-128LCT
• Anti-HER2 (trastuzumab)-mc-c-term-Dol15 ADC

• ADC-129LCT
• Anti-HER2 (trastuzumab)-mcc-DM1 ADC

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