Anti-HER2 (Trastuzumab)-CC-MMAD ADC (CAT#: ADC-126LCT)

• Antibody Overview
• Humanized (from Mouse) Anti-HER2

• Clone
• Trastuzumab

• Linker
• CC

• Drug
• MMAD (monomethyl auristatin D)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

• Alternative Names
• ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

• Gene ID
• 2064

• UniProt ID
• P04626

• ADC-132LCT
• Anti-HER2 (trastuzumab)-hydroxyl amino PEG linker-MMAD (monomethyl auristatin D) ADC

• ADC-133LCT
• Anti-HER2 (trastuzumab)-thioether SMCC linker-DM1 ADC

• ADC-101LCT
• Anti-HER2 (Trastuzumab)-MC-PEG8-Dol10 (Thiol Dol10) ADC

• ADC-134LCT
• Anti-HER2 (trastuzumab)-SPDP-DM1 ADC

• ADC-102LCT
• Anti-HER2 (Trastuzumab)-AO-MC-PEG8-Dol10 (Glyco Dol10) ADC

• ADC-135LCT
• Anti-HER2 (trastuzumab)-SPP-DM1 ADC

• ADC-103LCT
• Anti-HER2 (Trastuzumab)-MC-MMAE (Thiol MMAE) ADC

• ADC-136LCT
• Anti-HER2 (trastuzumab)-SSNPP-DM3 ADC

• ADC-104LCT
• Anti-HER2 (Trastuzumab)-AO-MC-MMAE (Glyco MMAE) ADC

• ADC-137LCT
• Anti-HER2 (trastuzumab)-SSNPP-DM4 ADC

• ADC-138LCT
• Anti-HER2 (trastuzumab)-auristatin ADC

• ADC-123LCT
• Anti-HER2 (trastuzumab)-bisAlk-vc-MMAE ADC

• ADC-127LCT
• Anti-HER2 (Trastuzumab)-mc-MMAD ADC

• ADC-128LCT
• Anti-HER2 (trastuzumab)-mc-c-term-Dol15 ADC

• ADC-129LCT
• Anti-HER2 (trastuzumab)-mcc-DM1 ADC

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