Anti-161P2F10B (clone H16-7.8)-mc-MMAF ADC
CAT#: ADC-036CL
This ADC product is composed of an anti-161P2F10B antibody (clone H16-7.8) conjugated via mc linker to MMAF (H16-7.8-MC-MMAF). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specifications
- Antibody Overview
- Anti-161P2F10B H16-7.8
- Clone
- H16-7.8
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in Kidney, Colon, Lung, Ovary, Breast, Lymphoma, Bone, Uterus, Pancreas, Liver, Prostate cancers.
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See other products for "161P2F10B"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0105CQ | Human Anti-161P2F10B Recombinant Antibody (HPAB-0105CQ) | ELISA, FC, Cyt, IP, Inhib, FuncS | Human IgG1, κ |
| HPAB-0106CQ | Human Anti-161P2F10B Recombinant Antibody (HPAB-0106CQ) | ELISA, FC, Cyt, Inhib, FuncS | Human IgG1, κ |
| HPAB-0107CQ | Human Anti-161P2F10B Recombinant Antibody (HPAB-0107CQ) | ELISA, FC, Cyt, IP, Inhib, FuncS | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0105CQ-F(E) | Human Anti-161P2F10B Recombinant Antibody; Fab Fragment (HPAB-0105CQ-F(E)) | ELISA, FC, Cyt, FuncS | Human Fab |
| HPAB-0106CQ-F(E) | Human Anti-161P2F10B Recombinant Antibody; Fab Fragment (HPAB-0106CQ-F(E)) | ELISA, FC, Cyt, FuncS | Human Fab |
| HPAB-0107CQ-F(E) | Human Anti-161P2F10B Recombinant Antibody; Fab Fragment (HPAB-0107CQ-F(E)) | ELISA, FC, Cyt, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0105CQ-S(P) | Human Anti-161P2F10B Recombinant Antibody; scFv Fragment (HPAB-0105CQ-S(P)) | ELISA, FC, Cyt, FuncS | Human scFv |
| HPAB-0106CQ-S(P) | Human Anti-161P2F10B Recombinant Antibody; scFv Fragment (HPAB-0106CQ-S(P)) | ELISA, FC, Cyt, FuncS | Human scFv |
| HPAB-0107CQ-S(P) | Human Anti-161P2F10B Recombinant Antibody; scFv Fragment (HPAB-0107CQ-S(P)) | ELISA, FC, Cyt, FuncS | Human scFv |
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