Anti-161P2F10B (clone H16-7.8)-mc-MMAF ADC (CAT#: ADC-036CL)

• Antibody Overview
• Anti-161P2F10B H16-7.8

• Clone
• H16-7.8

• Linker
• Mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in Kidney, Colon, Lung, Ovary, Breast, Lymphoma, Bone, Uterus, Pancreas, Liver, Prostate cancers.

Select a product category from the dropdown menu below to view related products.