Anti-24P4C12 (clone Ha5-l(5)2.1)-vc-MMAE ADC
CAT#: ADC-041CL
This ADC product is composed of an anti-24P4C12 antibody (clone Ha5-l(5)2.1) conjugated via vc linker to MMAE (Ha5-l(5)2.1vcMMAE). It has demonstrated a response in Colon, Pancreas, Ovarian, Breast, Lung, Prostate, Gastric cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specifications
- Antibody Overview
- 24P4C12 MAb Ha5-l(5)2.1. M Abs to 24P4C12 were generated using XenoMouse technology® (Amgem Fremont) wherein the Murine Heavy and kappa Light chain loci have been inactivated and a majority of the Human Heavy and kappa Light chain immunoglobulin loci have been inserted. The MAb designated Ha5-l(5)2.1 was generated from immunization of Human γ2 producing XenoMice with RAT(E)-24P4C12 cells.
- Clone
- Ha5-l(5)2.1
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in Colon, Pancreas, Ovarian, Breast, Lung, Prostate, Gastric cancers.
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "24P4C12"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP565-YC | Human Anti-24P4C12 Recombinant Antibody (HPAB-AP565-YC) | FC, IHC, FuncS | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP565-YC-S(P) | Human Anti-24P4C12 Recombinant Antibody; scFv Fragment (HPAB-AP565-YC-S(P)) | FC, IHC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP565-YC-F(E) | Human Anti-24P4C12 Recombinant Antibody; Fab Fragment (HPAB-AP565-YC-F(E)) | FC, IHC, FuncS | Human Fab |
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