This TNFα specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=0.1–0.5 nM) for TNFα as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-006 | Anti-Human TNF Recombinant Antibody (Infliximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
TAB-148CQ | Anti-Human TNF Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
TAB-402CQ | Human Anti-TNF Recombinant Antibody (TAB-402CQ) | ELISA | Chimeric (mouse/human) IgG |
TAB-148CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-402CQ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-311CT-F(E) | Anti-Human TNFα/RANKL Recombinant Antibody Fab Fragment (8G12) | Neut, ELISA, FC | |
TAB-271CQ | Rabbit Anti-TNF Recombinant Antibody (TAB-271CQ) | ELISA, Neut | Rabbit IgG |
TAB-123CQ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-123CQ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-130CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (m357) | ELISA, FC, Neut | |
TAB-132CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (MAK195) | ELISA, Neut |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-124CQ | Human Anti-TNF Recombinant Antibody (TAB-124CQ) | FuncS, Neut | Humanized antibody |
TAB-125CQ | Human Anti-TNF Recombinant Antibody (TAB-125CQ) | ELISA, Neut | Humanized antibody |
TAB-126CQ | Human Anti-TNF Recombinant Antibody (TAB-126CQ) | ELISA, Neut | Humanized antibody |
TAB-127CQ | Human Anti-TNF Recombinant Antibody (TAB-127CQ) | ELISA, Neut | Humanized antibody |
TAB-128CQ | Human Anti-TNF Recombinant Antibody (TAB-128CQ) | ELISA, FuncS | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-111CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (B5) | ELISA, WB | Human antibody |
TAB-113CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) | ELISA | Human Fab |
TAB-135CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (AE11-5) | ELISA, Neut | Human antibody |
TAB-136CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-136CQ-F(E)) | ELISA, Block | Human Fab |
TAB-137CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-137CQ-F(E)) | ELISA, FC, IF | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-083LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
Gly-085LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
Gly-086LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Gly-087LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Gly-163LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0609MZ | Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2051CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL589) | ELISA, ICC, Neut | Mouse IgG1 |
NEUT-2052CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL570) | WB, Neut | Mouse IgG2b |
NEUT-2053CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL571) | WB, Neut | Mouse IgG1 |
NEUT-2054CQ | Rat Anti-Tnf Recombinant Antibody (clone mAb0856) | Neut | Rat IgG1 |
NEUT-2108CQ | Mouse Anti-TNF Recombinant Antibody (clone mAb11) | ELISA, CyTOF, FC, ICFC, ICC, IF, IHC, Neut | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (clone XT3) | Block, ELISA, IHC, WB | Rat IgG1 |
NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
NEUT-2082CQ | Mouse Anti-TNF Recombinant Antibody (clone B-C7) | Block | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4460 | Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) | ELISA | Rabbit IgG |
MOR-4461 | Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) | Neut | Rabbit IgG |
MOR-4462 | Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) | FC | Rabbit IgG |
MOR-4463 | Rabbit Anti-TNF Recombinant Antibody (clone SI557DS) | FC | Rabbit IgG |
MOR-4464 | Rabbit Anti-TNF Recombinant Antibody (clone SI558DS) | FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-169CQ | Goat Anti-TNF Polyclonal Antibody, Biotin | WB, ELISA(Det), ICC | Goat IgG |
MOB-170CQ | Mouse Anti-TNF Recombinant Antibody (clone YC146), Biotin | Neut, ELISA, ICC, FC | Mouse IgG1, κ |
HPAB-0046-FY | Mouse Anti-TNF Recombinant Antibody (clone 1B7) | Neut | Mouse IgG |
HPAB-0675-CN | Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) | ELISA, Neut | Humanized IgG |
HPAB-0676-CN | Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) | ELISA, Neut | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0675-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0675-CN-F(E)) | ELISA, Neut | Humanized Fab |
HPAB-0676-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0676-CN-F(E)) | ELISA, Neut | Humanized Fab |
HPAB-0677-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0677-CN-F(E)) | ELISA, Neut | Humanized Fab |
HPAB-0678-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0678-CN-F(E)) | ELISA, Neut | Humanized Fab |
HPAB-0679-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0679-CN-F(E)) | ELISA, Neut | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-768 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-006 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0402-YC | Recombinant Chiloscyllium shark Anti-TNF Single Domain Antibody (3D2) | ELISA | Chiloscyllium shark vNAR single domain antibody |
HPAB-AP531-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC) | ELISA | Camel VHH |
HPAB-AP532-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP532-YC) | ELISA | Camel VHH |
HPAB-AP533-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP533-YC) | ELISA | Camel VHH |
HPAB-AP534-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP534-YC) | ELISA | Camel VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1615-FY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1615-FY-F(E)) | WB, ELISA | Human Fab |
HPAB-1807-FY-F(E) | Human Anti-TNF Recombinant Antibody (clone AB164); scFv Fragment | Neut | Human scFv |
FAMAB-0332JF-S(P) | Mouse Anti-TNF Recombinant Antibody (clone Di62); scFv Fragment | RIA, ELISA, FuncS | Mouse scFv |
HPAB-2087-FY-S(P) | Mouse Anti-TNF Recombinant Antibody (clone CB0010); scFv Fragment | Neut | Mouse scFv |
HPAB-1564WJ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (clone 3B10) | ELISA, WB, Neut | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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