Zybody

Creative Biolabs offers our expertise in Zybody design and construction for your research and development projects in both academic and clinical fields. We are confident to deliver you the best procedure to meet your individual requirements.

Zybody is engineered by fusing modular recognition domains (MRDs) to N- and C-termini of both the heavy and the light chains of a full-length monoclonal antibody (mAb). It is a multi-specific, multi-valent antibody format that enhances the activity of conventional mAb without compromising their desirable drug-like properties. The MRDs include small polypeptides sequences (< 60 amino acids), domain-based structures selected for target specificity, such as knottins or Protein A Scaffolds, unstructured (linear) or disulfide-constrained peptides. Zybodies possess up to four distinct specificities, depending on the number of MRDs fused to the mAb scaffold, while retaining the original functionality and specificity of the scaffold antibody.

Schematic representation of the Zybody Figure: Schematic representation of the Zybody (Landes Bioscience, 2013)

As one of the industry leaders, Creative Biolabs has unparalleled experience in bispecific antibody design and construction. We are confident to offer you a fast and efficient service to meet your required specifications.

Reference

  1. David LaFleur, et al. Monoclonal antibody therapeutics with up to five specificities Functional enhancement through fusion of target-specific peptides. MAbs. 2013 Mar-Apr;5(2):208-18.

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