PE-A*02:01/Human BCL2L1 (YLNDHLEPWI) MHC Tetramer
CAT#: MHC-CN0425
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72801/1349_F9_5_selected.jpg
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- BCL2L1
- Antigen Species
- Human
- Peptide
- YLNDHLEPWI
- Conjugate
- PE
- Application
- FCM, IHC
Target
- Antigen Introduction
- The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
- Alternative Names
- BCL2 Like 1; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; BCL2L; BCLX; Bcl-2-Like Protein 1;
- Gene ID
- 598
- UniProt ID
- Q07817
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Related Diseases
Amyotrophic Lateral Sclerosis
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Protocol & Troubleshooting
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0426 | APC-A*02:01/Human BCL2L1 (YLNDHLEPWI) MHC Tetramer | FCM, IHC | |
| MHC-CN0427 | FITC-A*02:01/Human BCL2L1 (YLNDHLEPWI) MHC Tetramer | FCM, IHC | |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY732 | Anti-Human BCL2L1 Immunohistochemistry Kit | IHC | |
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| VS13-YC97 | CytoStream™ Rabbit Anti-BCL2L1 Recombinant Antibody (VS13-YC97) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
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| VS-0425-YC20 | Recombinant Anti-BCL2L1 Vesicular Antibody, EV Displayed (VS-0425-YC20) | ELISA, FC, Cell-uptake |
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