APC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer

Name: APC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer
SKU: MHC-CN0614
Rating: 5 (1 reviews)

CAT#: MHC-CN0614

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg

Subcellular Location Figure 2 IHC staining of human placenta

Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG

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Specifications

Allele
A*02:01

Class
Class I

MHC Species
Human

Antigen
ENG

Antigen Species
Human

Peptide
LLTAALWYV

Conjugate
APC

Application
FCM, IHC

Target

Antigen Introduction
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Alternative Names
ENG; CD105 Antigen; Osler-Rendu-Weber Syndrome 1; HHT1; END; ORW; Endoglin; ORW1

Gene ID
2022

UniProt ID
P17813

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Downloadable Resources

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Datasheet

Datasheet - MHC-CN0614.pdf

MSDS

MSDS - MHC-CN0614.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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