A*02:01/Human ACTN4 (K5N) (FIASNGVKLV) MHC Pentamer (CAT#: MHC-YF314)

• Allele
• A*02:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• ACTN4 (K5N)

• Antigen Species
• Human

• Peptide
• FIASNGVKLV

• Range
• 118-127

• Conjugate
• Unlabeled, Biotin, R-PE, APC

• Application
• FCM

• Antigen Introduction
• Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

• Alternative Names
• Actinin Alpha 4; Focal Segmental Glomerulosclerosis 1; Non-Muscle Alpha-Actinin 4; Alpha-Actinin-4; ACTININ-4; FSGS1; FSGS;

• Gene ID
• 81

• UniProt ID
• O43707

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