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A*02:01/Human ACTN4 (K5N) (FIASNGVKLV) MHC Pentamer (CAT#: MHC-YF314)

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed ACTN4 (K5N)-derived peptide of FIASNGVKLV sequence covering 118-127 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.


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Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/63_D5_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Figure 2 IHC staining of human liver
(Immunohistochemical staining of human liver shows strong cytoplasmic and membranous positivity in bile duct cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/ihc_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/7921_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/7921_A_8_3.jpg
Figure 5 Liver
Figure 5 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/7921_A_9_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/7921_A_9_5.jpg
Figure 7 Testis
Figure 7 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/7921_A_6_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1873/7921_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A549)
Figure 9 RNA cell line category: Cell line enhanced (A549)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130402-ACTN4

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • ACTN4 (K5N)
  • Antigen Species
  • Human
  • Peptide
  • FIASNGVKLV
  • Range
  • 118-127
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • Actinin Alpha 4; Focal Segmental Glomerulosclerosis 1; Non-Muscle Alpha-Actinin 4; Alpha-Actinin-4; ACTININ-4; FSGS1; FSGS;

Downloads

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See other products for "ACTN4"

Recombinant Antibody

CAT Product Name Application Type
MOB-2028z Mouse Anti-ACTN4 Recombinant Antibody (clone 3B7) WB, ELISA, IF, IHC Mouse IgG1
HPAB-0073-CN Mouse Anti-ACTN4 Recombinant Antibody (clone N01) ELISA, IHC Mouse IgG2
HPAB-0187-LSX Mouse Anti-ACTN4 Recombinant Antibody (clone 13G9) ELISA, WB, IHC Mouse IgG
MRO-0064-CN Rabbit Anti-ACTN4 Recombinant Antibody (clone JU20-23) WB, IF, IP, IHC, FC Rabbit IgG
FAMAB-0057JF Human Anti-ACTN4 Recombinant Antibody (clone A2) WB, ELISA, IHC, IF Human IgM

Mouse Antibody

CAT Product Name Application Type
TAB-0357CL Anti-ACTN4 Recombinant Antibody IHC, ELISA
TAB-0357CL-S(P) Anti-ACTN4 Recombinant Antibody scFv Fragment IHC, ELISA
TAB-0651CLV Mouse Anti-ACTN4 Recombinant Antibody (TAB-0651CLV) WB, IHC Mouse IgG
TAB-0651CLV-F(E) Mouse Anti-ACTN4 Recombinant Antibody; Fab Fragment (TAB-0651CLV-F(E)) WB, IHC Mouse Fab
TAB-0651CLV-S(P) Mouse Anti-ACTN4 Recombinant Antibody; scFv Fragment (TAB-0651CLV-S(P)) WB, IHC Mouse scFv

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0057 Hi-Affi™ Rabbit Anti-ACTN4 Recombinant Antibody (clone DS57AB) ICC Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0073-CN-S(P) Mouse Anti-ACTN4 Recombinant Antibody (clone N01); scFv Fragment ELISA, IHC Mouse scFv
HPAB-0187-LSX-S(P) Mouse Anti-ACTN4 Recombinant Antibody (clone 13G9); scFv Fragment ELISA, WB, IHC Mouse scFv
HPAB-0188-LSX-S(P) Mouse Anti-ACTN4 Recombinant Antibody (clone 11H2); scFv Fragment ELISA, WB, IHC Mouse scFv
HPAB-0189-LSX-S(P) Mouse Anti-ACTN4 Recombinant Antibody (clone 9B3); scFv Fragment ELISA, WB, IHC Mouse scFv
FAMAB-0057JF-S(P) Human Anti-ACTN4 Recombinant Antibody (clone A2); scFv Fragment FC, WB, IHC, ELISA, FuncS Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0187-LSX-F(E) Mouse Anti-ACTN4 Recombinant Antibody (clone 13G9); Fab Fragment ELISA, WB, IHC Mouse Fab
HPAB-0188-LSX-F(E) Mouse Anti-ACTN4 Recombinant Antibody (clone 11H2); Fab Fragment ELISA, WB, IHC Mouse Fab
HPAB-0189-LSX-F(E) Mouse Anti-ACTN4 Recombinant Antibody (clone 9B3); Fab Fragment ELISA, WB, IHC Mouse Fab
HPAB-0190-LSX-F(E) Mouse Anti-ACTN4 Recombinant Antibody (clone 10E10); Fab Fragment ELISA, WB, IHC Mouse Fab
FAMAB-0057JF-F(E) Human Anti-ACTN4 Recombinant Antibody (clone A2); Fab Fragment FC, WB, IHC, ELISA, FuncS Human Fab

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