A*02:01/Human ACTN4 (K5N) (FIASNGVKLV) MHC Pentamer

CAT#: MHC-YF314

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed ACTN4 (K5N)-derived peptide of FIASNGVKLV sequence covering 118-127 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.

Gene Expression
Figure 1 IF staining of human cell line A-431 Figure 2 IHC staining of human liver Figure 3 Cerebral cortex Figure 4 Colon Figure 5 Liver Figure 6 Kidney Figure 7 Testis Figure 8 Lymph node Figure 9 RNA cell line category: Cell line enhanced (A549)

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • ACTN4 (K5N)
  • Antigen Species
  • Human
  • Peptide
  • FIASNGVKLV
  • Range
  • 118-127
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC

Target

  • Antigen Introduction
  • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • Actinin Alpha 4; Focal Segmental Glomerulosclerosis 1; Non-Muscle Alpha-Actinin 4; Alpha-Actinin-4; ACTININ-4; FSGS1; FSGS;
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