A*02:01/Human p53 (KLCPVQLWV) MHC Pentamer (CAT#: MHC-YF651)

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed p53-derived peptide of KLCPVQLWV sequence covering 139-147 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • p53
  • Antigen Species
  • Human
  • Peptide
  • KLCPVQLWV
  • Range
  • 139-147
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
  • Alternative Names
  • Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Cellular Tumor Antigen P53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome;

Related Resources

  • Related Diseases

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Single-domain Antibody

CAT Product Name Application Type
PNBL-072 Recombinant Anti-p53 VHH Single Domain Antibody (Nb139) Inhib, IP, WB, ELISA, FuncS Llama VHH
HPAB-0746-YJ-VHH Camelid Anti-TP53 Recombinant Single Domain Antibody (CBP71YJ) ELISA Camelid VHH

Rabbit Monoclonal Antibody

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0633CQ Mouse Anti-TP53 Recombinant Antibody (clone p53-11) WB Mouse IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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