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A*02:01/Human RNF43 (ALWPWLLMA) MHC Pentamer (CAT#: MHC-YF705)

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed RNF43-derived peptide of ALWPWLLMA sequence covering 11-19 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.


See more MHC Tetramer products for RNF43
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  • Gene Expression
  • Datasheet
  • MSDS
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Normal Tissue
Figure 1 IHC staining of human kidney
Figure 1 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong nuclear positivity in cells in tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_7_5_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_6_6.jpg
Figure 6 Lymph node
Figure 6 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A549, CACO-2, Hep G2, OE19)
Figure 7 RNA cell line category: Cell line enhanced (A549, CACO-2, Hep G2, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000108375-RNF43

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • RNF43
  • Antigen Species
  • Human
  • Peptide
  • ALWPWLLMA
  • Range
  • 11-19
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
  • Alternative Names
  • Ring Finger Protein 43; RING-Type E3 Ubiquitin Transferase RNF43; RING Finger Protein 43; E3 Ubiquitin-Protein Ligase RNF43; EC 2.3.2.27; RNF124; SSPCS; URCC;

Downloads

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See other products for "RNF43"

Mouse Antibody

CAT Product Name Application Type
TAB-327CT Mouse Anti-RNF43 Recombinant Antibody (TAB-327CT) WB, ELISA, FC, IHC, IP Mouse IgG
TAB-327CT-S(P) Mouse Anti-RNF43 Recombinant Antibody; scFv Fragment (TAB-327CT-S(P)) WB, ELISA, FC, IHC, IP Mouse scFv
TAB-327CT-F(E) Mouse Anti-RNF43 Recombinant Antibody; Fab Fragment (TAB-327CT-F(E)) WB, ELISA, FC, IHC, IP Mouse Fab

Humanized Antibody

CAT Product Name Application Type
TAB-328CT Humanized Anti-RNF43 Recombinant Antibody (TAB-328CT) WB, ELISA, FC, IHC, IP Humanized IgG1, κ
TAB-328CT-S(P) Humanized Anti-RNF43 Recombinant Antibody; scFv Fragment (TAB-328CT-S(P)) WB, ELISA, FC, IHC, IP Humanized scFv
TAB-328CT-F(E) Humanized Anti-RNF43 Recombinant Antibody; Fab Fragment (TAB-328CT-F(E)) WB, ELISA, FC, IHC, IP Humanized Fab

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN1185 PE-A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer FCM, IHC
MHC-CN1186 APC-A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer FCM, IHC
MHC-CN1187 FITC-A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer FCM, IHC
MHC-YF706 A*02:01/Human RNF43 (ALWPWLLMAT) MHC Pentamer FCM
MHC-YF707 A*24:02/Human RNF43 (722Y) (NYQPVWLCL) MHC Pentamer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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