APC-A*02:01/Human Elastin (GLGVGGLGV) MHC Tetramer
CAT#: MHC-CN0095
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56941/1527_F9_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human skin
Immunohistochemical staining of human skin shows distinct positivity in extracellular fibers.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18111/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows distinct positivity in extracellular fibers.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56941/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18111/40709_B_7_5.jpg
Normal Tissue
Figure 5 Testis
Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18111/40709_A_5_6.jpg
Normal Tissue
Figure 6 Cervix
Squamous epithelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18111/40709_B_8_3.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, BJ, fHDF/TERT166, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000049540-ELN
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Elastin
- Antigen Species
- Human
- Peptide
- GLGVGGLGV
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]
- Alternative Names
- ELN; Elastin; WS; Supravalvular Aortic Stenosis; Tropoelastin; Williams-Beuren Syndrome
- Gene ID
- 2006
- UniProt ID
- P15502
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