A*24:02/Human Papillomavirus type 16 E6 (VYDFAFRDL) MHC Pentamer (CAT#: MHC-YC189)
MHC multimers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a Pentamer of peptide/MHC complex with HPV16-derived peptide of VYDFAFRDL sequence covering 49-57 and A*24:02 molecule. The peptide/MHC pentamer provided here is unlabeled or fluorescent labeled such as Biotin, R-PE, APC. And all of them are available in 50, 150 or 500 tests.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Specifications
- Allele
- A*24:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- Human Papillomavirus type 16 E6
- Antigen Species
- HPV16
- Peptide
- VYDFAFRDL
- Range
- 49-57
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- E6 plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT)
- Alternative Names
- HpV16gp1
- Gene ID
- 1489078
- UniProt ID
- P03126
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-547LC | Anti-HPV16 E6 Recombinant Antibody (1B2.27) | ELISA | Mouse antibody |
| MRO-548LC | Anti-HPV16 E6 Recombinant Antibody (7F10.3) | ELISA | Mouse antibody |
| MRO-549LC | Anti-HPV16 E6 Recombinant Antibody (4E9.7) | ELISA | Mouse antibody |
| MRO-550LC | Anti-HPV16 E6 Recombinant Antibody (4E10.2) | ELISA | Mouse antibody |
| MRO-551LC | Anti-HPV16 E6 Recombinant Antibody (6H5.3) | ELISA | Mouse antibody |
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