A*24:02/Human TTK protein kinase (SYRNEIAYL) MHC Pentamer (CAT#: MHC-YF759)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed TTK protein kinase-derived peptide of SYRNEIAYL sequence covering 551-559 and A*24:02 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10166/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10166/if_selected.jpg
Figure 2 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_8_5.jpg
Figure 3 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_4_6.jpg
Figure 4 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_9_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_9_8.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112742-TTK
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112742-TTK
Specifications
- Allele
- A*24:02
- Class
- Class I
- Antigen
- TTK protein kinase
- Antigen Species
- Human
- Peptide
- SYRNEIAYL
- Range
- 551-559
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
- Alternative Names
- TTK Protein Kinase; Phosphotyrosine Picked Threonine-Protein Kinase; Monopolar Spindle 1 Kinase; Cancer/Testis Antigen 96; MPS1L1; MPS1; PYT; Phosphotyrosine Picked Threonine Kinase;
- Gene ID
- 7272
- UniProt ID
- P33981
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3212z | Mouse Anti-TTK Recombinant Antibody (clone 33D2) | WB, ICC, IF, IHC, IP, ELISA | Mouse IgG1 |
| ZG-477C | Mouse Anti-TTK Recombinant Antibody (clone 4E8E8) | ELISA | Mouse IgG1, κ |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1289 | PE-A*24:02/Human TTK (SYRNEIAYL) MHC Tetramer | FCM, IHC | |
| MHC-CN1290 | APC-A*24:02/Human TTK (SYRNEIAYL) MHC Tetramer | FCM, IHC | |
| MHC-CN1291 | FITC-A*24:02/Human TTK (SYRNEIAYL) MHC Tetramer | FCM, IHC | |
| MHC-CN1292 | A*24:02/Human TTK (SYRNEIAYL) MHC Tetramer | FCM, IHC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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