A*24:02/CMV IE-1 (AYAQKIFKI) MHC Monomer (CAT#: MHC-YF301)
This product is a MHC monomer of biotinylated peptide/MHC complex composed IE-1-derived peptide of AYAQKIFKI sequence covering 248-256 and A*24:02 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
Specifications
- Allele
- A*24:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- IE-1
- Antigen Species
- CMV
- Peptide
- AYAQKIFKI
- Range
- 248-256
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- It plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters.
- Alternative Names
- UL123; IE1; 55 kDa immediate-early protein 1
- UniProt ID
- P03169
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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