A*24:02/Human TTK (SYRNEIAYL) MHC Tetramer (CAT#: MHC-CN1292)
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Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10166/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10166/if_selected.jpg

Figure 2 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_8_5.jpg

Figure 3 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_4_6.jpg

Figure 4 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_9_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13229/34619_A_9_8.jpg

Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112742-TTK
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112742-TTK
Specifications
- Allele
- A*24:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- TTK
- Antigen Species
- Human
- Peptide
- SYRNEIAYL
- Conjugate
- Unconjugated
- Application
- FCM, IHC
Target
- Antigen Introduction
- This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
- Alternative Names
- TTK Protein Kinase; Phosphotyrosine Picked Threonine-Protein Kinase; Monopolar Spindle 1 Kinase; Cancer/Testis Antigen 96; MPS1L1; MPS1; PYT; Phosphotyrosine Picked Threonine Kinase;
- Gene ID
- 7272
- UniProt ID
- P33981
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