A*24:02/Human VEGFR (SYGVLLWEI) MHC Monomer

Name: A*24:02/Human VEGFR (SYGVLLWEI) MHC Monomer
SKU: MHC-YF304
Rating: 5 (1 reviews)

CAT#: MHC-YF304

This product is a MHC monomer of biotinylated peptide/MHC complex composed VEGFR-derived peptide of SYGVLLWEI sequence and A*24:02 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg

Normal Tissue Figure 2 Placenta

High expression

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR

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Specifications

Allele
A*24:02

Class
Class I

MHC Species
Human

Antigen
VEGFR

Antigen Species
Human

Peptide
SYGVLLWEI

Conjugate
Biotin

Application
MHC Multimer

Target

Antigen Introduction
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Alternative Names
FLK1; CD309; VEGFR; VEGFR2

UniProt ID
P35968

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Datasheet

Datasheet - MHC-YF304.pdf

MSDS

MSDS - MHC-YF304.pdf

COA

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