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Agonistic Antibody Products

Agonistic Antibody Overview

Cancer immunotherapy has significantly advanced with the development of both agonistic and antagonistic antibodies. While the first generations of immunotherapy agents primarily focused on blocking negative immune checkpoints like PD-1 and CTLA-4 with antagonist antibodies, a promising new frontier involves targeting co-stimulatory receptors with agonist antibodies. By stimulating immune cells and releasing the brakes on the immune response, these antibodies hold the potential to revolutionize cancer treatment by empowering the body's defenses to effectively combat malignant cells.

Fig.1 Negative and positive immune checkpoints targeted monoclonal antibodies in cancer therapy.Fig.1 Immune checkpoints targeted agonistic and antagonistic antibodies.1

The Molecular Mechanism of Agonistic & Antagonistic Antibody

Agonistic Antibody Antagonistic Antibody
Agonistic antibodies engage co-stimulatory receptors on T cells, triggering intracellular signaling cascades. This activation process induces T-cell proliferation and differentiation into effector cells. Activated T cells recognize and attack tumor cells, leading to their destruction. Antagonistic antibodies bind to immune checkpoints on T cells, preventing their interaction with their ligands. This blockade releases the inhibitory signals, allowing T cells to become activated. Activated T cells recognize and attack tumor cells, leading to their destruction.

Agonistic Antibody Production Service at Creative Biolabs

Creative Biolabs stands out as a leading supplier of premium antibodies tailored for the global research sector. Leveraging our state-of-the-art eukaryotic cell expression technology and vast experience, we provide efficient and reliable services for the expression and purification of agonistic antibodies. Starting from initial antibody sequences, we offer a full suite of solutions encompassing gene construction, expression, purification, and quality assessment. Flexible, we customize the quantity and concentration to satisfy your specific demands on downstream applications. Backed up by our robust platform and seasoned experts, we have great confidence in the delivery of high-purity, low-endotoxin agonistic antibodies to accelerate biopharmaceutical research and development.

Fig.2 Process. (Creative Biolabs Original)Fig.2 Our service process.

Our Advanced Eukaryotic Cell Expression Platform

Creative Biolabs leverages advanced eukaryotic cell expression technologies to deliver high-quality agonistic antibodies. Our expertise lies in utilizing mammalian cell lines, primarily HEK293 and CHO cells, to produce complex proteins with accurate post-translational modifications, essential for their biological activity. In addition to mammalian cell lines, we also offer alternative insect cell lines that can be used for rapid, high-yield production, especially for simpler proteins.

  • HEK293 cells
  • CHO cells
  • Sf9 insect cells

Benefits for You

  • Industry regulatory specifications-compliant working conditions and procedures.
  • Produce agonistic antibodies on a flexible scale.
  • Selective eukaryotic cell expression systems.
  • Customized service process.
  • Excellent agonistic antibody production in both quality and quantity.

What Customer Say

Ma***s 17/Oct/2024 ⭐⭐⭐⭐⭐

I just got the purified agonist antibodies from Creative Biolabs. I am very satisfied with their quality and potency. These antibodies performed excellently in my WB and FC tests, with no background interference and strong specificity. When I first contacted Creative Biolabs for their agonistic antibody expression and purification service, their team was able to tailor their services to meet my needs, including custom protein modifications and purification strategies. Throughout the project, the project manager kept me informed and swiftly addressed all my queries and worries. The delivery time was also in my desire This is a happy collaboration experience for me.

As a leading supplier in the field of antibody research, Creative Biolabs is committed to producing high-quality antibodies to accelerate drug development and preclinical research processes. If you want to know more about our reliable agonistic antibody products or production service, please feel free to get in touch with us.

Reference
  1. Marhelava, Katsiaryna, et al. "Targeting negative and positive immune checkpoints with monoclonal antibodies in therapy of cancer." Cancers 11.11 (2019): 1756. Distributed under Open Access License CC BY 4.0, without modification.

PRODUCT LIST

Target Catalog No. Target Catalog No. Target Catalog No.
CD27 CBMAB-096LC CD40 TAB-152 4-1BB TAB-179
CBMAB-105LC
TAB-H74 TAB-199LC TAB-457CQ
LTBR CBMAB-098LC CBMAB-106LC MPL CBMAB-108LC
CBMAB-099LC TAB-126CL CBMAB-109LC
LTBR CBMAB-100LC CBMAB-107LC CBMAB-110LC
FAS CBMAB-103LC OX40 CBMAB-101LC DR4 TAB-H48
PABC-193 DR6 TAB-631CL
DR5 CBMAB-104LC CBMAB-102LC GITR TAB-629CL
PABL-030 TAB-633CL TSHR PABW-172
TAB-203 TrkB TAB-180CQ TAB-190CQ
TAB-180 TrkC TAB-183CQ TAB-189CQ
TAB-196 TAB-184CQ TWEAKR TAB-627CL
TAB-195 TAB-185CQ TWEAK TAB-178
TAB-625CL TAB-182CQ Tnfrsf1a CBMAB-097LC
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