AI-based High Throughput Antibody Affinity Maturation Service
Creative Biolabs utilizes state-of-the-art automation and artificial intelligence (AI) technologies to rapidly produce and screen many antibodies for affinity maturation.
Antibody Affinity Maturation
Antibody affinity maturation is a process by which antibodies undergo genetic mutations to increase their affinity for a specific antigen. During the immune response to antigens, the process takes place in germinal centers within the secondary lymphoid organs. As B cells undergo somatic hypermutation and selection, antibodies with higher affinity for the antigen are selected for, leading to a more effective immune response. Over time, the process results in the production of antibodies with higher affinity and specificity for antigens.
Proven Technology Platform at Creative Biolabs
AI-based antibody affinity matured high-throughput antibody production services utilize AI algorithms to screen and identify high-affinity antibodies for specific targets. This technology accelerates the process of antibody discovery and optimization, resulting in the production of highly efficient antibodies for various applications. By combining AI and high-throughput technologies, Creative Biolabs quickly identifies and produces large quantities of antibodies with improved efficacy and specificity.
Process of Our Service
Our service begins with the design and construction of antibody libraries using cutting-edge molecular biology techniques. These libraries are then expressed in our high-throughput mammalian cell culture system, allowing us to produce hundreds to thousands of unique antibodies simultaneously. Once the antibodies are produced, we employ our AI algorithms to screen them for affinity to the target antigen.
01
Generation of diverse antibody library
A diverse antibody library is generated using phage display or yeast display technology.
02
Iterative cycles of selection and optimization
The identified antibodies are then subjected to iterative cycles of selection and optimization to further
03
Scale-up and production
Once the optimized antibodies have been validated, they can be scaled up for production using mammalian cell expression systems.
04
Delivery of final antibody candidates
The final affinity-mature antibody is delivered to the customer.
05
Identification of target antibody
The first step in the process is to identify the target antibody that needs to undergo affinity maturation.
06
High throughput screening
The antibody library is screened using high throughput methods to identify antibodies with improved binding affinity to the target antigen.
07
Validation of improved antibodies
The selected antibodies with improved binding affinity are validated through functional assays to ensure their specificity, stability, and efficacy.
08
Characterization and optimization
The affinity-matured antibodies are further characterized to assess their pharmacokinetic properties, stability, and immunogenicity.
Advantages of Our Service
Speed and Efficiency
Our service can rapidly analyze large datasets to identify antibodies with high binding affinities, saving time and resources compared to traditional methods.
Improved Accuracy
Our service can quickly and accurately identify promising antibody candidates, reducing the risk of false positives and streamlining the selection process.
Customization
Our service can be tailored to specific research needs, allowing for the development of antibodies optimized for a particular target or application.
Cost-Effectiveness
Our services can reduce the overall cost of antibody development by minimizing the need for labor-intensive and time-consuming experiments.
Scalability
Our service can handle large amounts of data and can easily scale up to accommodate high-throughput screening, making it suitable for projects of any size.
Cooperation With Creative Biolabs
Contact Us
Our team of experienced scientists and engineers provide high-quality antibodies for a wide range of applications, including therapeutic development, diagnostics, and research. Contact us now to learn more about our high throughput antibody production service for AI-based antibody affinity maturation.
For research use only. Not intended for any clinical use.
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