AI-based High Throughput Antibody Physicochemical Properties Analysis and Engineering Service

AI-powered tools harness sophisticated data on developability attributes, allowing for detailed profiling of antibodies and providing key insights into their therapeutic potential. Creative Biolabs delivers a cost-effective high throughput antibody production service for AI-based antibody physicochemical properties analysis and engineering to support global customers in the identification and advancement of powerful and effective antibodies.

Current Status of Antibody Development

Antibody therapeutics have rapidly become the leading category of biopharmaceuticals, driven by advancements in monoclonal antibody technology. Innovations such as antibody-drug conjugates, and multi-specific antibodies have further expanded this field. However, accurately characterizing the critical quality attributes of these antibody products presents significant challenges and is essential for the successful development and commercialization of antibody-based therapies.

Fig.1 Schematic representation of various local microenvironments and physiological factors that can influence antibody-target engagement in vivo. (Dunlap & Yanguang, 2022)Fig.1 Illustration depicting the diverse local microenvironments and physiological variables that affect antibodies-antigens interaction in living organisms.1, 2

Physicochemical Properties of Antibody

  • The structural characterization of antibody drugs
Complete molecular weight, Light chain molecular weight; Heavy chain molecular weight; Amino acid sequence; Disulfide bond; Free thiol group; Glycosylation site; N-terminal sequencing; post-translational modification; Secondary and tertiary structure characterization.
  • Variant analysis
Body size variants; Charge variants; etc.
  • Aggregation analysis
Aggregates formed by spatial complementarity and charge complementarity caused by spatial changes in proteins
  • Impurities
Residual DNA and proteins from the host cell; Protein A introduced during purification
  • General properties
pH value; osmotic pressure; appearance; viscosity; etc.

High Throughput Antibody Production Service for AI-based Antibody Physicochemical Properties Analysis and Engineering at Creative Biolabs

Creative Biolabs' high-throughput antibody production service harnesses the power of cutting-edge AI technology to analyze and engineer vast antibody sequences, refining their physicochemical properties for optimal performance. This streamlined approach empowers us to swiftly identify the best candidates for large-scale production, dramatically reducing both development time and costs. In just two weeks, we can adeptly produce over 1,000 recombinant antibodies from a diverse array of AI-optimized sequences. Our comprehensive quality control system ensures that every stage of production adheres to the highest standards, while our state-of-the-art laboratories and skilled research team work collaboratively to meet the unique needs of our clients, effectively propelling their research initiatives to new heights.

Key Features

Fig.2 Our service advantages. (Creative Biolabs Original)

  • High Throughput Technology: These services utilize automated systems for the rapid production of antibodies, allowing for the generation of diverse antibody candidates in a fraction of the traditional time and cost.
  • AI Integration: AI-based analysis helps in predicting the physicochemical properties of antibodies, optimizing their stability, affinity, and specificity. Machine learning techniques analyze previous data to enhance the development and optimization of antibodies for upcoming uses.
  • Physicochemical Properties Analysis: Understanding the physicochemical properties, such as solubility, viscosity, and pH stability, is essential for the successful development of therapeutic antibodies.
  • Streamlined Workflow: The combination of high-throughput techniques with AI enhances the workflow from antibody generation through characterization and leads to quicker decision-making in the development process.
  • Flexibility and Customization: Services are customized to meet the unique requirements of customers, catering to areas such as research, therapeutic innovation, and diagnostics.
  • Customer Review

★★★★

  • Sh*****d 22/May/2024

I recently collaborated with Creative Biolabs for their high-throughput antibody production service, focusing on AI-driven analysis of physicochemical properties. The experience was outstanding, with a professional team that genuinely understood our needs and customized their approach accordingly. The AI insights significantly enhanced our antibody engineering, providing valuable data for optimization. The quality of the produced antibodies was excellent, consistently meeting our specifications with remarkable reproducibility. Additionally, the transparent pricing and comprehensive documentation facilitated a smooth process.

If you're seeking a reliable high throughput antibody production service for AI-based antibody physicochemical properties analysis and engineering, we invite you to reach out to us for potential collaboration!

References
  1. Dunlap, Tyler, and Yanguang Cao. "Physiological considerations for modeling in vivo antibody-target interactions." Frontiers in pharmacology 13 (2022): 856961.
  2. under Open Access License CC BY 4.0, without modification.

For research use only. Not intended for any clinical use.

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