Human Anti-α5β1 Recombinant Antibody (clone M200) (CAT#: HPAB-1873-FY)
This product is a recombinant antibody that recognizes α5β1. The monoclonal antibody M200 reacts with the epitope of α5β1.
Specific Inquiry
Inhib
Figure 1 Illustrates results of M200 is a potent inhibitor of endothelial cell growth, encompassing the anti-proliferative properties of an anti-VEGF mAb, HuMV833.
Inhib
Figure 2 Illustrates results showing that M200 inhibits VEGF induced cell growth.
Cyt
Figure 3 Illustrates results showing: quantification of annexin stained cells by flow cytometry.
Cyt
Figure 4 Illustrates results showing M200 causes increased cell death in proliferating versus senescent HUVEC.
ELISA
Figure 5 Depicts results of a competition ELISA binding assay comparing binding affinities of mouse antibody IIA1, chimeric antibody M200 (200-4 EOS), and two humanized versions of M200: huM200-G4 and huM200-g2m3G.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Human IgG
- Specificity
- Human α5β1
- Species Reactivity
- Human
- Clone
- M200
- Applications
- Inhib, Cyt, ELISA
- Related Disease
- Diabetic retinopathy, macular degeneration due to neovascularization
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The α5β1 antibody has been reported in applications of Inhibition, Cytotoxicity, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Integrin α5β1; GPV/IIIa; GPV/Iia
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone M200"
See other products for "α5β1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1059 | Recombinant Anti-α5β1 Antibody | WB, IF, FuncS | IgG |
| MHH-1059 | Recombinant Human Anti-α5β1 Antibody | ELISA, IF, FuncS | IgG |
| HPAB-1869-FY | Mouse Anti-α5β1 Recombinant Antibody (clone 11A1) | ELISA | Mouse IgG |
| HPAB-1870-FY | Human Anti-α5β1 Recombinant Antibody (clone 200-4) | ELISA | Human IgG4 |
| HPAB-1871-FY | Mouse Anti-α5β1 Recombinant Antibody (clone F200) | Inhib | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-1059-F(E) | Recombinant Human Anti-α5β1 Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| HPAB-0023-YJ-F(E) | Human Anti-α5β1 Recombinant Antibody; Fab Fragment (HPAB-0023-YJ-F(E)) | FuncS | Chimeric (mouse/human) Fab |
| HPAB-0049-YJ-F(E) | Mouse Anti-α5β1 Recombinant Antibody (clone B9); Fab Fragment | ELISA, Neut, IHC, FC, Inhib | Mouse Fab |
| HPAB-0420-YJ-F(E) | Human Anti-α5β1 Recombinant Antibody (clone MOR04974); Fab Fragment | ELISA, IP, FC, IHC, Block, FuncS | Human Fab |
| HPAB-0421-YJ-F(E) | Human Anti-α5β1 Recombinant Antibody (clone MOR04977); Fab Fragment | ELISA, IP, FC, IHC, Block, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-741 | Mouse Anti-α5β1 Recombinant Antibody (clone SG/19); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0420-YJ-S(P) | Human Anti-α5β1 Recombinant Antibody (clone MOR04974); scFv Fragment | ELISA, IP, FC, IHC, Block, FuncS | Human scFv |
| HPAB-0421-YJ-S(P) | Human Anti-α5β1 Recombinant Antibody (clone MOR04977); scFv Fragment | ELISA, IP, FC, IHC, Block, FuncS | Human scFv |
| HPAB-1873-FY-F(E) | Mouse Anti-α5β1 Recombinant Antibody (clone M200); scFv Fragment | ELISA, Inhib | Mouse scFv |
| HPAB-2115-FY-S(P) | Human Anti-α5β1 Recombinant Antibody (clone 2H12); scFv Fragment | Inhib, ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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