Anti-67LR/37LBP (clone W24V302) Recombinant Antibody Coupled Liposome (VS-1024-FY292)
CAT#: VS-1024-FY292
The anti-67LR/37LBP coupled liposome refers to a technique that links anti-67LR (67 kDa Laminin Receptor) to liposomes, which are nanoscale vesicles commonly used for drug delivery. This coupling method helps improve the targeting of drugs, allowing them to more effectively localize to specific cells or tissues, particularly in cancer treatment and other related medical applications.
More Infomation
Specifications
- Potential Clinical Applications
- Antibody-conjugated liposomes targeting 67LR/37LBP have the potential to selectively kill breast cancer cells.
Product Composition
- Clone
- W24V302
- Antibody Type
- IgG
- Antibody Host
- Rabbit
- Antibody Reactivity
- Human
- Antibody Description
- This antibody can specifically recognize and bind to 37LBP, aiding in the study of its biological functions in cancer cells. The application of antibody can help reveal the role of the 67 kDa laminin receptor (67LR) in cancer progression. Through this antibody, researchers can gain deeper insights into the potential mechanisms of 37LBP in cancer invasiveness and metastatic potential.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- 67LR/37LBP
- Introduction
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
- Alternative Names
- Ribosomal Protein SA; Laminin Receptor 1 (67kD, Ribosomal Protein SA); Multidrug Resistance-Associated Protein MGr1-Ag; Colon Carcinoma Laminin-Binding Protein; Laminin-Binding Protein Precursor P40; Small Ribosomal Subunit Protein US2; 37/67 KDa Laminin Receptor; 7 KDa Laminin Receptor; NEM/1CHD4; LBP/P40; LRP/LR; LAMR1; 37LRP
- Full Name
- Ribosomal Protein SA
- Gene ID
- 3921
- UniProt ID
- P08865
- Sequence Similarities
- Belongs to the universal ribosomal protein uS2 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Nucleus
- Post Translation Modifications
- Acylated
- Protein Refseq
- NP_001291217.1; NP_002286.2
- Function
- Required for the assembly and/or stability of the 40S ribosomal subunit.
Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
Also functions as a cell surface receptor for laminin.
Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways.
May play a role in cell fate determination and tissue morphogenesis.
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