Anti-Robo4-SPDB-DM4 ADC
CAT#: ADC-267CL
This ADC product is composed of an anti-Robo4 antibody conjugated via SPDB linker to DM4(anti-Robo4-SPDB-DM4). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
❮
❯
Specifications
- Antibody Overview
- Anti-Robo4 Antibody,
- Linker
- SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Linker Class/Description
- Class: Chemically cleavable linkers-Disulfide Linkers
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.
- Alternative Names
- ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;
- Gene ID
- 54538
- UniProt ID
- B4DYV8
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-267CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ROBO4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT | Mouse Anti-Robo4 Recombinant Antibody (TAB-329CT) | WB, ELISA, FC, IHC | Mouse IgG2a |
| TAB-329CT-S(P) | Mouse Anti-Robo4 Recombinant Antibody; scFv Fragment (TAB-329CT-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| TAB-329CT-F(E) | Mouse Anti-Robo4 Recombinant Antibody; Fab Fragment (TAB-329CT-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-330CT | Anti-Human Robo4 Recombinant Antibody (YW79.11) | WB, ELISA, FC | Human antibody |
| TAB-330CT-S(P) | Anti-Human Robo4 Recombinant Antibody scFv Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| TAB-330CT-F(E) | Anti-Human Robo4 Recombinant Antibody Fab Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4396 | Hi-Affi™ Recombinant Rabbit Anti-ROBO4 Monoclonal Antibody (SI487DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-076CN | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22) | FC, ELISA, FuncS | Human IgG |
| NS-076CN-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); Fab Fragment | FC, ELISA | Human Fab |
| NS-076CN-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); scFv Fragment | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ | Human Anti-ROBO4 Recombinant Antibody (HPAB-0045-WJ) | ELISA, RIA | Humanized IgG2, κ |
| HPAB-J0217-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6) | ELISA | Human IgG |
| HPAB-J0218-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW71.1) | ELISA | Human IgG |
| HPAB-J0219-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW79.1) | ELISA | Human IgG |
| HPAB-1902-FY | Human Anti-ROBO4 Recombinant Antibody (clone MR7) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-S(P) | Human Anti-ROBO4 Recombinant Antibody; scFv Fragment (HPAB-0045-WJ-S(P)) | ELISA, RIA | Humanized scFv |
| HPAB-N0234-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody; scFv Fragment (HPAB-N0234-YC-S(P)) | FC, Activ | Humanized scFv |
| HPAB-AP412-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-AP413-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1902-FY-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone MR7); scFv Fragment | ELISA, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-0045-WJ-F(E)) | ELISA, RIA | Humanized Fab |
| HPAB-N0234-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-N0234-YC-F(E)) | FC, Activ | Humanized (mouse/human) Fab |
| HPAB-J0217-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); Fab Fragment | ELISA | Human Fab |
| HPAB-J0218-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.1); Fab Fragment | ELISA | Human Fab |
| HPAB-J0219-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW79.1); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC496 | Recombinant Anti-ROBO4 Vesicular Antibody, EV Displayed (VS-0425-YC496) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
-CB2006C17L-4.jpg)
Application: WB, ELISA
Application: ELISA, Neut
-2.png)
Application: ELISA
Application: ELISA, FC, WB, Inhib, IHC
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
Application: ELISA, WB, IF, FC, IP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
