Anti-Robo4-SPDP-NCS ADC (CAT#: ADC-151LZY)

• Antibody Overview
• Anti-Robo4 IgG

• Antibody Isotype
• IgG

• Linker
• SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)

• Linker Class/Description
• Class: Chemically cleavable Linker-Disulfide Linker
  Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• NCS

• Drug Class/Description
• Class: Neocarzinostatin
  Description: Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.

• Introduction
• ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.

• Alternative Names
• ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;

• Gene ID
• 54538

• UniProt ID
• B4DYV8

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