Anti-Robo4-SPDP-NCS ADC
CAT#: ADC-151LZY
This ADC product is composed of an anti-Roundabout homolog 4 (Robo4) antibody conjugated via SPDP
linker to NCS (anti-Robo4-SPDP-NCS). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of inhibiting DNA synthesis .
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
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Specifications
- Antibody Overview
- Anti-Robo4 IgG
- Antibody Isotype
- IgG
- Linker
- SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- NCS
- Drug Class/Description
- Class: Neocarzinostatin
Description: Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.
Target
- Introduction
- ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.
- Alternative Names
- ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;
- Gene ID
- 54538
- UniProt ID
- B4DYV8
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Datasheet
MSDS
COA
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See other products for "ROBO4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT | Mouse Anti-Robo4 Recombinant Antibody (TAB-329CT) | WB, ELISA, FC, IHC | Mouse IgG2a |
| TAB-329CT-S(P) | Mouse Anti-Robo4 Recombinant Antibody; scFv Fragment (TAB-329CT-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| TAB-329CT-F(E) | Mouse Anti-Robo4 Recombinant Antibody; Fab Fragment (TAB-329CT-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-330CT | Anti-Human Robo4 Recombinant Antibody (YW79.11) | WB, ELISA, FC | Human antibody |
| TAB-330CT-S(P) | Anti-Human Robo4 Recombinant Antibody scFv Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| TAB-330CT-F(E) | Anti-Human Robo4 Recombinant Antibody Fab Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4396 | Hi-Affi™ Recombinant Rabbit Anti-ROBO4 Monoclonal Antibody (SI487DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-076CN | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22) | FC, ELISA, FuncS | Human IgG |
| NS-076CN-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); Fab Fragment | FC, ELISA | Human Fab |
| NS-076CN-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); scFv Fragment | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ | Human Anti-ROBO4 Recombinant Antibody (HPAB-0045-WJ) | ELISA, RIA | Humanized IgG2, κ |
| HPAB-N0234-YC | Human Anti-ROBO4 Recombinant Antibody (HPAB-N0234-YC) | FC, Activ | Humanized (mouse/human) IgG |
| HPAB-AP412-YC | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| HPAB-AP413-YC | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2) | ELISA, FC | Chimeric (mouse/human) IgG2 |
| HPAB-J0217-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-S(P) | Human Anti-ROBO4 Recombinant Antibody; scFv Fragment (HPAB-0045-WJ-S(P)) | ELISA, RIA | Humanized scFv |
| HPAB-N0234-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody; scFv Fragment (HPAB-N0234-YC-S(P)) | FC, Activ | Humanized scFv |
| HPAB-AP412-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-AP413-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-J0217-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-0045-WJ-F(E)) | ELISA, RIA | Humanized Fab |
| HPAB-N0234-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-N0234-YC-F(E)) | FC, Activ | Humanized (mouse/human) Fab |
| HPAB-AP412-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-AP413-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-J0217-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC496 | Recombinant Anti-ROBO4 Vesicular Antibody, EV Displayed (VS-0425-YC496) | ELISA, FC, Cell-uptake |
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