Rat Anti-ACVR1 Recombinant Antibody (clone 0443)
CAT#: VS-0724-YC41
The product is a a rat anti-ALK2 antibody clone 0443. clone 0443 specifically bind mouse and human ALK2 among ALK1 through ALK7 with KD values of 5.1 and 5.6 nM, respectively. Clone 0443 is a blocking monoclonal antibody that can selectively suppress ALK2 signaling and prevents ligand-induced heterotopic ossification. Clone 0443 can induce dimerization of ALK2 extracellular domains in a back-to-back orientation on the cell membrane by binding the residues H64 and F63 on opposite faces of the ligand-binding site. Clone 0443 could prevent heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva that carries the human R206H pathogenic mutant.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoli & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46514/804_D7_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7505/21979_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7505/21979_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7505/21979_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7505/21979_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7505/21979_A_6_6.jpg
Normal Tissue
Figure 7 Smooth muscle
Smooth muscle cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7505/21979_B_6_7.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115170-ACVR1
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Specifications
- Immunogen
- 6x His-tagged mouse ALK2 ECD fused to human IgG Fc.
- Host Species
- Rat
- Derivation
- Hybridoma
- Type
- Rat IgG
- Specificity
- Mouse and human ACVR1
- Species Reactivity
- Mouse, Human
- Clone
- clone 0443
- Applications
- ELISA, WB, Block, ICC, FC
- Related Disease
- Fibrodysplasia ossificans progressiva, Diffuse intrinsic pontine glioma
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
- Gene ID
- 90
- UniProt ID
- Q04771
- Long Name
- Activin receptor-like kinase 2 (ALK2)
- Sequence Similarities
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
- Cellular Localization
- Membrane; Single-pass type I membrane protein
- Post Translation Modifications
- Glycosylation at Asn102.
- Protein Refseq
- NP_001096.1; NP_001104537.1; NP_001334592.1; NP_001334593.1; NP_001334594.1
- Function
- Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation.
As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B.
Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain.
In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal.
In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor.
Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs.
May promote the expression of HAMP, potentially via its interaction with BMP6.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ACVR1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0426MZ | Mouse Anti-ACVR1 Recombinant Antibody (clone NN0063-0K28) | IHC-P, WB | Mouse IgG1 |
| HPAB-0230-CN | Human Anti-Acvr1 Recombinant Antibody (HPAB-0230-CN) | ELISA, FC | Chimeric (Rat/Human) IgG1, κ |
| HPAB-0231-CN | Human Anti-Acvr1 Recombinant Antibody (HPAB-0231-CN) | ELISA, FC | Chimeric (Rat/Human) IgG1, κ |
| HPAB-0698LY | Mouse Anti-ACVR1 Recombinant Antibody (HPAB-0698LY) | ELISA, FC | Mouse IgG1 |
| HPAB-0699LY | Mouse Anti-ACVR1 Recombinant Antibody (HPAB-0699LY) | ELISA, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0061 | Hi-Affi™ Rabbit Anti-ACVR1 Recombinant Antibody (clone DS61AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0230-CN-F(E) | Human Anti-Acvr1 Recombinant Antibody; Fab Fragment (HPAB-0230-CN-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
| HPAB-0231-CN-F(E) | Human Anti-Acvr1 Recombinant Antibody; Fab Fragment (HPAB-0231-CN-F(E)) | ELISA, FC | Chimeric (Rat/Human) Fab |
| HPAB-0705LY-F(E) | Human Anti-ACVR1 Recombinant Antibody; Fab Fragment (HPAB-0705LY-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0706LY-F(E) | Human Anti-ACVR1 Recombinant Antibody; Fab Fragment (HPAB-0706LY-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0707LY-F(E) | Human Anti-ACVR1 Recombinant Antibody; Fab Fragment (HPAB-0707LY-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0228-CN-S(P) | Rat Anti-Acvr1 Recombinant Antibody; scFv Fragment (HPAB-0228-CN-S(P)) | ELISA, FC | Rat scFv |
| HPAB-0229-CN-S(P) | Rat Anti-Acvr1 Recombinant Antibody; scFv Fragment (HPAB-0229-CN-S(P)) | ELISA, FC | Rat scFv |
| HPAB-0232-CN-S(P) | Human Anti-Acvr1 Recombinant Antibody; scFv Fragment (HPAB-0232-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0233-CN-S(P) | Human Anti-Acvr1 Recombinant Antibody; scFv Fragment (HPAB-0233-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0698LY-S(P) | Mouse Anti-ACVR1 Recombinant Antibody; scFv Fragment (HPAB-0698LY-S(P)) | ELISA, FC | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY36 | Anti-ACVR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY133 | Anti-Human ACVR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC602 | Recombinant Anti-Acvr1 Vesicular Antibody, EV Displayed (VS-0425-YC602) | ELISA, FC, Cell-uptake |
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