Rat Anti-ACVR1 Recombinant Antibody (clone 0443) (CAT#: VS-0724-YC41)

• Immunogen
• 6x His-tagged mouse ALK2 ECD fused to human IgG Fc.

• Host Species
• Rat

• Derivation
• Hybridoma

• Type
• Rat IgG

• Specificity
• Mouse and human ACVR1

• Species Reactivity
• Mouse, Human

• Clone
• clone 0443

• Applications
• ELISA, WB, Block, ICC, FC

• Related Disease
• Fibrodysplasia ossificans progressiva, Diffuse intrinsic pontine glioma

• Purification
• Protein G purified

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2

• Gene ID
• 90

• UniProt ID
• Q04771

• Long Name
• Activin receptor-like kinase 2 (ALK2)

• Sequence Similarities
• Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

• Cellular Localization
• Membrane; Single-pass type I membrane protein

• Post Translation Modifications
• Glycosylation at Asn102.

• Protein Refseq
• NP_001096.1; NP_001104537.1; NP_001334592.1; NP_001334593.1; NP_001334594.1

• Function
• Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation.
  As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B.
  Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain.
  In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal.
  In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor.
  Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs.
  May promote the expression of HAMP, potentially via its interaction with BMP6.

Isotype Control

• MOB-209CQ
• Rat IgG1, kappa Isotype Control Antibody

Secondary Antibody

• 2ND-068CQ
• Goat Anti-Rat IgG (H&L) Antibody

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