Mouse Anti-ADAM10 Recombinant Antibody (VS3-FY2620) (CAT#: VS3-FY2620)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• ADAM metallopeptidase domain 10 of human

• Species Reactivity
• Human

• Applications
• IHC, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 37.7 kDa.

• Related Disease
• Reticulate Acropigmentation Of Kitamura and Alzheimer Disease 18

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• ADAM Metallopeptidase Domain 10; Mammalian Disintegrin-Metalloprotease; Kuzbanian Protein Homolog; EC 3.4.24.81; CDw156; MADM; Kuz; Disintegrin And Metalloproteinase Domain-Containing Protein 10; A Disintegrin And Metalloproteinase Domain 10; A Disintegrin And Metalloprotease Domain 10

• Gene ID
• 102

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein
  Golgi apparatus membrane; Single-pass type I membrane protein
  Cytoplasmic vesicle, clathrin-coated vesicle
  Cell projection, axon
  Cell projection, dendrite
  Cell junction, adherens junction
  Cytoplasm

• Post Translation Modifications
• The precursor is cleaved by furin and PCSK7.
  Glycosylation at Ser36, Thr130, Asn439, Asn551, Asn267, and Asn278
  Ubiquitination at Lys410 and Lys601
  Modification sites at PhosphoSitePlus
  Glycosylation from Gly
  Glycosylation from GlyGen 13 sites, 6 N-linked glycans (2 sites), 3 O-linked glycans (7 sites)

• Protein Refseq
• NP_001101.1; NP_001307499.1

• Function
• Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity).
  Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177).
  Enhances the cleavage of CHL1 by BACE1 (By similarity).
  Cleaves NRCAM (By similarity).
  Cleaves TREM2, resulting in shedding of the TREM2 ectodomain

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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