Mouse Anti-ADAM10 Recombinant Antibody (VS3-FY2620)
CAT#: VS3-FY2620
The product is a recombinant mouse monoclonal antibody that binds to ADAM10. The calculated molecular weight of the protein is 37.7 kDa. It cross-reacts with human. This monoclonal antibody is potential for conducting research on Reticulate Acropigmentation Of Kitamura and Alzheimer Disease 18. This monoclonal antibody can be used in Immunohistochemistry, Flow cytometry, ELISA.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/50670/757_F11_4_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/211_C7_2_selected.jpg
Normal Tissue
Figure 3 IHC staining of human stomach
Immunohistochemical staining of human stomach shows moderate cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137845-ADAM10
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- ADAM metallopeptidase domain 10 of human
- Species Reactivity
- Human
- Applications
- IHC, FC, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 37.7 kDa.
- Related Disease
- Reticulate Acropigmentation Of Kitamura and Alzheimer Disease 18
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- ADAM Metallopeptidase Domain 10; Mammalian Disintegrin-Metalloprotease; Kuzbanian Protein Homolog; EC 3.4.24.81; CDw156; MADM; Kuz; Disintegrin And Metalloproteinase Domain-Containing Protein 10; A Disintegrin And Metalloproteinase Domain 10; A Disintegrin And Metalloprotease Domain 10
- Gene ID
- 102
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Golgi apparatus membrane; Single-pass type I membrane protein
Cytoplasmic vesicle, clathrin-coated vesicle
Cell projection, axon
Cell projection, dendrite
Cell junction, adherens junction
Cytoplasm
- Post Translation Modifications
- The precursor is cleaved by furin and PCSK7.
Glycosylation at Ser36, Thr130, Asn439, Asn551, Asn267, and Asn278
Ubiquitination at Lys410 and Lys601
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 13 sites, 6 N-linked glycans (2 sites), 3 O-linked glycans (7 sites)
- Protein Refseq
- NP_001101.1; NP_001307499.1
- Function
- Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity).
Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177).
Enhances the cleavage of CHL1 by BACE1 (By similarity).
Cleaves NRCAM (By similarity).
Cleaves TREM2, resulting in shedding of the TREM2 ectodomain
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "ADAM10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2188z | Mouse Anti-ADAM10 Recombinant Antibody (clone 8A6) | WB, ELISA, IHC | Mouse IgG1 |
| MOB-0433MZ | Mouse Anti-ADAM10 Recombinant Antibody (clone 22H3) | FC, IHC-P, IP, WB | Mouse IgG1 |
| MRO-1627-CN | Rabbit Anti-ADAM10 Polyclonal Antibody (MRO-1627-CN) | WB, IHC | Rabbit IgG |
| PABS-0194 | Mouse Anti-ADAM10 Recombinant Antibody (PABS-0194) | IP, WB, FC, ELISA | Mouse IgG |
| VS7-HM38 | Mouse Anti-ADAM10 Recombinant Antibody (clone 6C3C7) | IHC, FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B003(A) | Recombinant Anti-human ADAM10 Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B003(G) | Recombinant Anti-human ADAM10 Intrabody [+36 GFP] | FACS, ELISA, IF, FuncS | scFv-(+36GFP) |
| IAB-B003(T) | Recombinant Anti-human ADAM10 Intrabody [Tat] | FACS, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0068 | Hi-Affi™ Rabbit Anti-ADAM10 Recombinant Antibody (clone DS68AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0101-YJ-S(P) | Mouse Anti-ADAM10 Recombinant Antibody; scFv Fragment (HPAB-0101-YJ-S(P)) | IP, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0101-YJ-F(E) | Mouse Anti-ADAM10 Recombinant Antibody; Fab Fragment (HPAB-0101-YJ-F(E)) | IP, Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY40 | Anti-ADAM10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY146 | Anti-Mouse ADAM10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY145 | Anti-Human ADAM10 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC400 | Recombinant Anti-ADAM10 Vesicular Antibody, EV Displayed (VS-0425-YC400) | ELISA, FC, Cell-uptake |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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