Can I use this antibody to inhibit the ADCYAP1R1 receptor in a cell-based assay?

Yes, this antibody is designed for that purpose. The listed applications are 'Block' and 'FuncS' (functional study), indicating its validation for use in assays that involve modulating the receptor's function, such as blocking ligand binding or signaling. It is a human IgG2 antibody.

What is the target of this antibody?

This antibody targets ADCYAP1R1, which is the gene name for the PAC1 receptor. This is a G protein-coupled receptor (GPCR) that binds to PACAP (Pituitary adenylate cyclase-activating polypeptide). It's a significant target in neuroscience and endocrinology research. This antibody reacts with the human form of the receptor.

Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0432-YJ)

CAT#: HPAB-0432-YJ

This product is a recombinant human antibody that binds to human PAC1. The antibody can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line SH-SY5Y

Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30739/1735_E10_1_selected.jpg

Normal Tissue Figure 2 High expression in cerebral cortex

Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_B_7_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_9_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_9_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_4_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078549-ADCYAP1R1

❮

❯

Specifications

Immunogen
PAC1 extracellular domain protein.

Host Species
Human

Type
Human IgG2, κ

Specificity
Human ADCYAP1R1

Species Reactivity
Human

Applications
Block, FuncS

Related Disease
Migraine

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
PAC1; PAC1R; PACAPR; PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP receptor 1; PACAP type I receptor; PACAP-R1; adenylate cyclase; activating polypeptide 1 (pituitary) receptor type I; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; pituitary adenylate cyclase-activating; polypeptide type 1 receptor

Gene ID
117

UniProt ID
P41586

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for HPAB-0432-YJ. Click the button above to contact us or submit your feedback about this product.

Breast cancer biomarkers at key points during disease progression

Good for Blocking Assays

This human IgG2 antibody (HPAB-0432-YJ) is exactly what we needed for our PAC1 receptor research. It is validated for blocking (Block) and functional studies (FuncS). We have used it to successfully modulate receptor activity in our human cell lines. A high-quality reagent.

Functional PAC1 Receptor Ab

Finding functional-grade antibodies for GPCRs can be challenging. This human antibody against ADCYAP1R1 (PAC1 receptor) is specified for functional studies (FuncS) and blocking, which is perfect for our research. Its human origin (IgG2, kappa) is ideal for our human-cell-based assays.

Q&As

Can I use this antibody to inhibit the ADCYAP1R1 receptor in a cell-based assay?

A: Yes, this antibody is designed for that purpose. The listed applications are 'Block' and 'FuncS' (functional study), indicating its validation for use in assays that involve modulating the receptor's function, such as blocking ligand binding or signaling. It is a human IgG2 antibody.
What is the target of this antibody?

A: This antibody targets ADCYAP1R1, which is the gene name for the PAC1 receptor. This is a G protein-coupled receptor (GPCR) that binds to PACAP (Pituitary adenylate cyclase-activating polypeptide). It's a significant target in neuroscience and endocrinology research. This antibody reacts with the human form of the receptor.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# HPAB-0432-YJ, RRID: AB_3713830)

Copy citation

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0432-YJ.pdf

MSDS

MSDS - HPAB-0432-YJ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "ADCYAP1R1"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-3850z	Mouse Anti-ADCYAP1R1 Recombinant Antibody (clone 15H5)	WB, IP, ELISA	Mouse IgG1, κ

CAT	Product Name	Application	Type
TAB-0917CL	Anti-Human ADCYAP1R1 Recombinant Antibody (2C)	Competitive ELISA

CAT	Product Name	Application	Type
TAB-0918CL	Human Anti-ADCYAP1R1 Recombinant Antibody (TAB-0918CL)	ChIP	Human IgG1

CAT	Product Name	Application	Type
TAB-0919CL	Human Anti-ADCYAP1R1 Recombinant Antibody (TAB-0919CL)	cAMP functional assay	Human IgG2

CAT	Product Name	Application	Type
TAB-0917CL-S(P)	Anti-Human ADCYAP1R1 Recombinant Antibody scFv Fragment (2C)	Competitive ELISA

CAT	Product Name	Application	Type
TAB-0918CL-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (TAB-0918CL-S(P))	cAMP functional assay	Human scFv

CAT	Product Name	Application	Type
TAB-0919CL-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (TAB-0919CL-S(P))	cAMP functional assay	Human scFv

CAT	Product Name	Application	Type
TAB-0917CL-F(E)	Anti-Human ADCYAP1R1 Recombinant Antibody Fab Fragment (2C)	Competitive ELISA

CAT	Product Name	Application	Type
TAB-0918CL-F(E)	Human Anti-ADCYAP1R1 Recombinant Antibody; Fab Fragment (TAB-0918CL-F(E))	cAMP functional assay	Human Fab

CAT	Product Name	Application	Type
Gly-189LC	Recombinant Anti-Human ADCYAP1R1 Antibody (Non-glycosylated)	ELISA	Human antibody
Gly-190LC	Recombinant Anti-Human ADCYAP1R1 Antibody (Non-glycosylated)	ELISA	Human antibody
Gly-191LC	Recombinant Anti-Human ADCYAP1R1 Antibody (Non-glycosylated)	ELISA	Human antibody
Gly-192LC	Recombinant Anti-Human ADCYAP1R1 Antibody (Non-glycosylated)	ELISA	Human antibody
Gly-193LC	Recombinant Anti-Human ADCYAP1R1 Antibody (Non-glycosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
MOB-1526CT	Mouse Anti-ADCYAP1R1 Recombinant Antibody (clone EML304)	IF, WB	Mouse IgG1

CAT	Product Name	Application	Type
HPAB-0039CQ	Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0039CQ)	ELISA, Block	Human IgG1, κ

CAT	Product Name	Application	Type
HPAB-0039CQ-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (HPAB-0039CQ-S(P))	ELISA, Block	Human scFv

CAT	Product Name	Application	Type
HPAB-0039CQ-F(E)	Human Anti-ADCYAP1R1 Recombinant Antibody; Fab Fragment (HPAB-0039CQ-F(E))	ELISA, Block	Human Fab, κ

CAT	Product Name	Application	Type
HPAB-0431-YJ	Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0431-YJ)	Block, FuncS	Human IgG2, κ

CAT	Product Name	Application	Type
HPAB-0431-YJ-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (HPAB-0431-YJ-S(P))	Block, FuncS	Human scFv

CAT	Product Name	Application	Type
HPAB-0432-YJ-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (HPAB-0432-YJ-S(P))	Block, FuncS	Human scFv

CAT	Product Name	Application	Type
HPAB-0431-YJ-F(E)	Human Anti-ADCYAP1R1 Recombinant Antibody; Fab Fragment (HPAB-0431-YJ-F(E))	Block, FuncS	Human Fab

CAT	Product Name	Application	Type
HPAB-0432-YJ-F(E)	Human Anti-ADCYAP1R1 Recombinant Antibody; Fab Fragment (HPAB-0432-YJ-F(E))	Block, FuncS	Human Fab

CAT	Product Name	Application	Type
HPAB-0437YY	Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0437YY)	Inhib, FC	Humanized IgG

CAT	Product Name	Application	Type
HPAB-0437YY-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (HPAB-0437YY-S(P))	Neut	Human scFv

CAT	Product Name	Application	Type
HPAB-0440YY-S(P)	Human Anti-ADCYAP1R1 Recombinant Antibody; scFv Fragment (HPAB-0440YY-S(P))	Neut	Human scFv

CAT	Product Name	Application	Type
HPAB-0437YY-F(E)	Human Anti-ADCYAP1R1 Recombinant Antibody; Fab Fragment (HPAB-0437YY-F(E))	Neut	Humanized Fab

CAT	Product Name	Application	Type
HPAB-0440YY-F(E)	Human Anti-ADCYAP1R1 Recombinant Antibody; Fab Fragment (HPAB-0440YY-F(E))	Neut	Humanized Fab

CAT	Product Name	Application	Type
VS-0424-XY7	AbPlus™ Anti-ADCYAP1R1 Magnetic Beads (VS-0424-XY7)	ChIP, Protein Purification

CAT	Product Name	Application	Type
VS-0425-YC565	Recombinant Anti-ADCYAP1R1 Vesicular Antibody, EV Displayed (VS-0425-YC565)	ELISA, FC, Neut, Cell-uptake

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 1 Recombinant Anti-5-FU Antibody (MOB-12) in ELISA

Recombinant Anti-5-FU Antibody (CAT# MOB-12)
Application: WB, Neut, FuncS

Figure 3 Anti-Human IL17RA Antibody (TAB-134) in DB

Human Anti-IL17RA Recombinant Antibody (TAB-134) (CAT# TAB-134)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 3 Anti-Human NCAM1 Therapeutic Antibody (TAB-188) in ELISA

Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) (CAT# TAB-188)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-Human CD19 Recombinant Antibody (TAB-108CL) in ELISA

Anti-Human CD19 Recombinant Antibody (TAB-108CL) (CAT# TAB-108CL)
Application: FC, ADCC, FuncS

Figure 2 CD276 Recombinant Antibody (TAB-117CL) in HPLC

Anti-Human CD276 Recombinant Antibody (TAB-117CL) (CAT# TAB-117CL)
Application: ADCC, FuncS

Figure 5 Human Anti-HIV Env Recombinant Antibody (PABL-509) in ELISA

Human Anti-HIV Env Recombinant Antibody (clone PGT121) (CAT# PABL-509)
Application: ELISA, Neut

Figure 2 Human Anti-CD3 Recombinant Antibody (TAB-0416CL-S(P)) in WB

Mouse Anti-CD3 Recombinant Antibody scFv Fragment (TAB-0416CL-S(P)) (CAT# TAB-0416CL-S(P))
Application: IB, ELISA, FC, FuncS

Figure 2 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in HPLC

Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1611CL-F(E)) (CAT# TAB-1611CL-F(E))
Application: Depletion, FuncS

Figure 2 Anti-Human SIRPA Recombinant Antibody Fab Fragment (TAB-453CT-F(E)) in HPLC

Human Anti-SIRPA Recombinant Antibody; Fab Fragment (TAB-453CT-F(E)) (CAT# TAB-453CT-F(E))
Application: WB, ELISA

Figure 2 Anti-Human CCP Recombinant Antibody (TAB-393CQ) in HPLC

Anti-Human CCP Recombinant Antibody (A02) (CAT# TAB-393CQ)
Application: ELISA, IHC

Figure 2 Anti-Human SLC34A2 Recombinant Antibody (TAB-467MZ) in HPLC

Mouse Anti-SLC34A2 Recombinant Antibody (TAB-467MZ) (CAT# TAB-467MZ)
Application: FC, Inhib

Figure 5 Human Anti-Mouse Prnp Recombinant Antibody Fab Fragment (D18) (MRO-944LC-F(E)) in DB

Anti-Mouse Prnp Recombinant Antibody Fab Fragment (D18) (CAT# MRO-944LC-F(E))
Application: ELISA

Figure 1 Anti-BNP Antibody (PABX-017) in ELISA

Recombinant Mouse Anti-BNP Antibody (106.3) (CAT# PABX-017)
Application: FuncS

Figure 5 Human Anti-FGFR2 Recombinant Antibody (NS-027CN) in Dot Blot

Human Anti-FGFR2 Recombinant Antibody (clone M048-D01) (CAT# NS-027CN)
Application: ELISA, WB, FC

Figure 2 CD19 Humanized Antibody (HPAB-0036LY) in HPLC

Recombinant Humanized Anti-CD19 Antibody (HPAB-0036LY) (CAT# HPAB-0036LY)
Application: WB, IHC

Figure 2 Human Anti-HLA-DR4 Recombinant Antibody (HPAB-0827-FY) in HPLC

Human Anti-HLA-DR4/GAD-555-567 Recombinant Antibody (clone G1H12) (CAT# HPAB-0827-FY)
Application: FC

Figure 1 Rabbit Anti-ASFV p72 Polyclonal Antibody (CBPAB-401CQ) in ELISA

Rabbit Anti-ASFV p72 Polyclonal Antibody (CAT# CBPAB-401CQ)
Application: ELISA, WB

Figure 4 Human Anti-PEG Recombinant Antibody (FAMAB-1525CQ) in ELISA

Human Anti-PEG Recombinant Antibody (clone E11) (CAT# FAMAB-1525CQ)
Application: WB, ELISA, FC

Figure 4 Human Anti-FZD5 Recombinant Antibody (PABJ-0145) in ELISA

Human Anti-FZD5 Recombinant Antibody (PABJ-0145) (CAT# PABJ-0145)
Application: ELISA, Inhib, FuncS

Figure 2 Anti-FAP Antibody in ELISA.

Mouse Anti-FAP Recombinant Antibody (clone F19) (CAT# HPAB-A1368-YJ)
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.