Rabbit Anti-ADRA1A Recombinant Antibody (clone R04-8B8) (CAT#: VS3-FY1645)
This incredible rabbit recombinant monoclonal antibody is appropriate for validation in immunohistochemistry (IHC) studies. It is capable of binding to human and rat ADRA1A. The R04-8B8 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100).
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Subcellular Location
Normal Tissue
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76693/1958_G3_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76693/1958_G3_2_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in astrocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in astrocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/ihc_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_B_7_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_B_7_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_A_4_6.jpg
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29679/70377_A_4_6.jpg
Specifications
- Immunogen
- Synthetic peptide of human α1a adrenergic receptor
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat ADRA1A
- Species Reactivity
- Human, Rat
- Clone
- R04-8B8
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- MW
- The calculated weight of the target protein is approximately 51 kDa, while the observed molecular weight stands at 51 kDa.
- Related Disease
- Ureterolithiasis and Central Nervous System Origin Vertigo
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Adrenoceptor Alpha 1A; Adrenergic, Alpha-1A-, Receptor; Alpha-1C Adrenergic Receptor; Alpha-1A Adrenoreceptor; Alpha-1A Adrenoceptor; ADRA1C
- Gene ID
- 148
- UniProt ID
- P35348
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane, Nucleus
- Post Translation Modifications
- C-terminal Ser or Thr residues may be phosphorylated.
- Protein Refseq
- NP_000671.2; NP_001309431.1; NP_001309432.1; NP_001309433.1; NP_150645.2
- Function
- This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G11 proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0090 | Hi-Affi™ Rabbit Anti-ADRA1A Recombinant Antibody (clone DS90AB) | WB, ICC, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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