Anti-AGR2 (clone 18A4Hu1) Recombinant Antibody Coupled Liposome (VS-1024-FY58)
CAT#: VS-1024-FY58
Liposomal formulations combined with anti-AGR2 antibodies have potential applications in the treatment of breast cancer. AGR2 (anterior gradient 2) is a protein associated with breast cancer and has been studied as a tumor-associated antigen in several cancers. Therefore, utilizing liposomes coupled with anti-AGR2 antibodies can enable targeted drug delivery, enhancing therapeutic efficacy while reducing side effects.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/1873_D5_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of cell line RT4
Immunofluorescent staining of cell line RT4 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/1386_F6_1_blue_red_green.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining:Medium
Intensity: Moderate
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/24377_A_9_3.jpg
Normal Tissue
Figure 4 Prostate
Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/24377_A_3_5.jpg
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- 18A4Hu1
- Antibody Type
- IgG1, kappa
- Antibody Host
- Humanized
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant human antibody specifically designed to identify and bind to the protein AGR2 (Anterior Gradient 2). AGR2 is known to play a crucial role in various biological processes, including protein folding, cellular signaling, and tumor progression. By utilizing advanced recombinant DNA technology, this antibody is engineered to enhance specificity and affinity for AGR2, making it an invaluable tool for research and clinical applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- AGR2
- Introduction
- This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
- Alternative Names
- Anterior Gradient 2, Protein Disulphide Isomerase Family Member; Protein Disulfide Isomerase Family A, Member 17; Secreted Cement Gland Protein XAG-2 Homolog; HAG-2; AG-2; HPC8; AG2; Anterior Gradient 2 Homolog (Xenopus Laevis); Anterior Gradient Protein 2 Homolog
- Full Name
- Anterior Gradient 2, Protein Disulphide Isomerase Family Member
- Gene ID
- 10551
- UniProt ID
- O95994
- Sequence Similarities
- Belongs to the AGR family.
- Cellular Localization
- Endoplasmic reticulum
- Positive Control
- The positive control samples for this antibody include K562, C6 lysates.
- Post Translation Modifications
- Disulfide bond
- Protein Refseq
- NP_006399.1
- Function
- Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity).
Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| HPAB-0316-WJ-S(P) | Mouse Anti-AGR2 Recombinant Antibody; scFv Fragment (HPAB-0316-WJ-S(P)) | ELISA, Block | Mouse scFv |
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| HPAB-0316-WJ-F(E) | Mouse Anti-AGR2 Recombinant Antibody; Fab Fragment (HPAB-0316-WJ-F(E)) | ELISA, Block | Mouse Fab |
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| VS-0525-XY218 | Anti-Human AGR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY220 | Anti-Rat AGR2 Immunohistochemistry Kit | IHC |
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