Anti-AKT1 (clone W24V162) Recombinant Antibody Coupled Liposome (VS-1024-FY163) (CAT#: VS-1024-FY163)

• Potential Clinical Applications
• Melanoma

• Clone
• W24V162

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse monoclonal antibody specifically designed to target the AKT1 protein. AKT1, also known as Protein Kinase B alpha, plays a crucial role in various cellular processes, including metabolism, cell proliferation, and survival signaling.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• AKT1

• Introduction
• The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

• Alternative Names
• AKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase

• Full Name
• AKT Serine/Threonine Kinase 1

• Gene ID
• 207

• UniProt ID
• P31749

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane, Nucleus

Select a product category from the dropdown menu below to view related products.