Anti-ALB Antibody Prodrug, Protease Activated (VS-1025-YC116)

Name: Anti-ALB Antibody Prodrug, Protease Activated (VS-1025-YC116)
SKU: VS-1025-YC116
Rating: 5 (1 reviews)

CAT#: VS-1025-YC116

The Anti-ALB Antibody Prodrug, Protease Activated (VS-1025-YC116) is an antibody prodrug comprised of a recombinant human antibody targeting human Albumin, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to ALB protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to ALB effectively. Albumin is the most abundant protein in plasma and is generally not involved in oncogenic signaling, but it is critically important in the oncological setting due to its role in drug delivery. It is used as a carrier for various chemotherapies and its levels often reflect the overall nutritional status of cancer patients.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line Hep G2

Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum & the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31024/763_G10_1_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human fallopian tube

Immunohistochemical staining of human fallopian tube shows distinct positivity in plasma.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6262/17728_A_9_7_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31024/128566_B_7_5.jpg

Normal Tissue Figure 4 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31024/128566_A_7_3.jpg

Normal Tissue Figure 5 Kidney

Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity:>75%
Proximal tubules (microvilli)
Staining:Medium
Intensity: Moderate

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31024/128566_A_7_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31024/128566_A_6_6.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enriched (Hep G2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163631-ALB

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Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human Albumin

Target
ALB

Species Reactivity
Human

Isotype
IgG

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
ALB (Albumin) is a Protein Coding gene. Diseases associated with ALB include Analbuminemia and Hyperthyroxinemia, Familial Dysalbuminemic. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include enzyme binding and chaperone binding. An important paralog of this gene is AFP.

Alternative Names
Albumin; ALB; HAS

Gene ID
213

UniProt ID
P02768

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Datasheet

Datasheet - VS-1025-YC116.pdf

MSDS

MSDS - VS-1025-YC116.pdf

COA

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