Human Anti-ALCAM Recombinant Antibody (VS-0524-YC42)
CAT#: VS-0524-YC42
The antibody bound to human activated leukocyte cell adhesion molecule and exhibited a damaging effect by the ADCC activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/52_B2_2_selected.jpg
Normal Tissue
Figure 2 Parathyroid gland
High expression in parathyroid gland
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_1_8_val_selected.jpg
Normal Tissue
Figure 3 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_7_5.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_B_7_5.jpg
Normal Tissue
Figure 5 Stomach
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_6_1.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10926/26851_A_9_4.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (hTERT-HME1, U-138 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170017-ALCAM
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human activated leukocyte cell adhesion molecule
- Species Reactivity
- Human
- Applications
- FC, ADCC
- Related Disease
- Parasitic Conjunctivitis and Stork Bite.
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The ADCC activity of this antibody was investigated using NCI-H1373 (pulmonary adenocarcinoma), CW2 (large bowel cancer) and NCI-H441 (lung cancer) cells.
Target
- Alternative Names
- Activated Leukocyte Cell Adhesion Molecule; CD166 Antigen; MEMD; Activated Leucocyte Cell Adhesion Molecule; CD166;
- Gene ID
- 214
- UniProt ID
- Q13740
- Long Name
- Activated leukocyte cell adhesion molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn361, Asn91, Asn95, Asn167, Asn457, Asn480, Asn499, Asn265, and Asn306
- Protein Refseq
- NP_001230209.1; NP_001230210.1; NP_001230212.1; NP_001618.2
- Function
- Mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts.
Inhibits activities of membrane-bound isoforms by competing for the same interaction partners.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| FN-021CQ | Mouse Anti-ALCAM Recombinant Antibody (clone 3A6) | FC, Block | Mouse IgG1 |
| MOR-0012-FY | Mouse Anti-ALCAM Recombinant Antibody (clone AZN-L50) | FC, FuncS, IF, IP, WB | Mouse IgG2a |
| ZG-0372F | Mouse Anti-ALCAM Recombinant Antibody (ZG-0372F) | IHC, ELISA | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-031CL | Human Anti-ALCAM Recombinant Antibody (TAB-031CL) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-019CQ | Mouse Anti-ALCAM Recombinant Antibody (clone CBL314) | WB, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0134 | Hi-Affi™ Rabbit Anti-ALCAM Recombinant Antibody (clone DS134AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0273 | APC-H-2Kd/Human CD166 (SLNVSAISI) MHC Tetramer | FCM | |
| MHC-CN0274 | PE-H-2Kd/Human CD166 (SLNVSAISI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0951-FY-F(E)) | IHC | Human Fab |
| HPAB-0952-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0952-FY-F(E)) | IHC | Human Fab |
| HPAB-0953-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0953-FY-F(E)) | IHC | Human Fab |
| HPAB-0954-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0954-FY-F(E)) | IHC | Human Fab |
| HPAB-0955-FY-F(E) | Human Anti-ALCAM Recombinant Antibody; Fab Fragment (HPAB-0955-FY-F(E)) | IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0951-FY-S(P)) | IHC | Human scFv |
| HPAB-0952-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0952-FY-S(P)) | IHC | Human scFv |
| HPAB-0953-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0953-FY-S(P)) | IHC | Human scFv |
| HPAB-0954-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0954-FY-S(P)) | IHC | Human scFv |
| HPAB-0955-FY-S(P) | Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0955-FY-S(P)) | IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC794 | AbPlus™ Anti-Alcam Magnetic Beads (VS-0724-YC794) | IP, Protein Purification | |
| VS-0724-YC999 | AbPlus™ Anti-ALCAM Magnetic Beads (VS-0724-YC999) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC19 | Rabbit Anti-ALCAM Antibody (VS-0924-YC19) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC532 | Recombinant Anti-ALCAM Vesicular Antibody, EV Displayed (VS-0425-YC532) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY289 | Anti-ALCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY290 | Anti-Mouse ALCAM Immunohistochemistry Kit | IHC |
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