Human Anti-ALKBH3 Recombinant Antibody (clone VS0724W1) (CAT#: VS-0724-FY31)
This is a noval human antibody that exhibits high affinity for ALKBH3. ALKBH3 (AlkB Homolog 3) is an enzyme that modifies DNA and RNA. It demethylates DNA and RNA, thereby affecting biological processes such as RNA transcription and translation and DNA repair. Researchers usually study ALKBH3 antibodies to understand its expression and function in cells. ALKBH3 antibodies can be used to study the localization of ALKBH3 protein in cells, interacting proteins, and involved biological functions.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human ALKBH3
- Species Reactivity
- Human
- Clone
- VS0724W1
- Applications
- Immunoassay
- Related Disease
- Prostate Cancer and Prostate Carcinoma In Situ
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase; Alkylated DNA Repair Protein AlkB Homolog 3; DEPC-1; DEPC1; HABH3; ABH3; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3
- Gene ID
- 221120
- UniProt ID
- Q96Q83
- Long Name
- AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination.
OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'-polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_631917.1
- Function
- Has a strong preference for single-stranded DNA.
Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3.
Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA.
Also acts on RNA.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY100 | Anti-ALKBH3 Immunohistochemistry Kit | IHC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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