Anti-ANGPT2 (clone MEDI1/5) Recombinant Antibody Coupled Liposome (VS-1024-FY280)
CAT#: VS-1024-FY280
Anti-Ang-2 antibody conjugated liposomes hold significant potential in the treatment of neovascular age-related macular degeneration (AMD) by targeting pathways that promote angiogenesis and inflammation. These liposomes can facilitate targeted delivery of therapeutic agents directly to the neovascular tissues, minimizing systemic side effects and enhancing localized treatment efficacy.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27034_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (HMC-1, HSkMC, HUVEC TERT2, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091879-ANGPT2
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More Infomation
Specifications
- Potential Clinical Applications
- Neovascular age-related macular degeneration (neovascular AMD)
Product Composition
- Clone
- MEDI1/5
- Antibody Type
- IgG1
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was specifically engineered to target Angiopoietin-2 (Ang-2), a pivotal protein involved in angiogenesis and vascular permeability. By precisely binding to Ang-2, this antibody aims to inhibit its interactions with its receptors and mitigate the pathological effects associated with excessive angiogenesis, which is often observed in various diseases, including cancer and inflammatory conditions.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ANGPT2
- Introduction
- The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
- Alternative Names
- Angiopoietin 2; ANG-2; Angiopoietin-2B; Angiopoietin-2a; Angiopoietin-2; Tie2-Ligand; AGPT2; ANG2
- Full Name
- Angiopoietin 2
- Gene ID
- 285
- UniProt ID
- O15123
- Sequence Similarities
- The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn89, Asn151, Asn119, Asn133, Asn240, and Asn304 ( NX_O15123 [NX_O15123-1] )
Modification sites at PhosphoSitePlus ( O15123 )
Glycosylation from GlyConnect ANGP2_HUMAN (664)
Glycosylation from GlyGen (O15123) 7 sites, 23 N-linked glycans (4 sites), 1 O-linked glycan
- Protein Refseq
- NP_001112359.1; NP_001112360.1; NP_001138.1; NP_001373264.1; NP_001373265.1
- Function
- Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, 19116766, 19223473, 9204896).
Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, 19116766, 19223473, 9204896).
In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression.
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Datasheet
MSDS
COA
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Lot Number:
See other products for "Clone MEDI1/5"
- CAT
- Product Name
See other products for "ANGPT2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1042 | Recombinant Mouse Anti-Human ANGPT2 Antibody Fab Fragment | ELISA, Biosensors | Fab |
| HPAB-0111CQ-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (HPAB-0111CQ-F(E)) | ELISA, Neut, WB | Human Fab |
| HPAB-0112CQ-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (HPAB-0112CQ-F(E)) | ELISA, Neut, WB | Human Fab |
| HPAB-0172-WJ-F(E) | Mouse Anti-ANGPT2 Recombinant Antibody (clone 10D6); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0486-WJ-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (HPAB-0486-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-070 | Recombinant Anti-human ANGPT2 VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| TAB-0032CL-VHH | Anti-Human ANGPT2 VHH Single Domain Antibody | ELISA, Block, SPR | Single domain antibody |
| TAB-0035CL-VHH | Anti-Human ANGPT2 VHH Single Domain Antibody | ELISA, Block, SPR | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-077CT | Anti-Human ANG2 Recombinant Antibody (1A2) | ELISA, WB | Human antibody |
| TAB-0867CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0867CLV-F(E)) | ELISA | Human Fab |
| TAB-0869CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0869CLV-F(E)) | SPR, Inhib, FuncS | Human Fab |
| TAB-0870CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0870CLV-F(E)) | FuncS | Human Fab |
| TAB-0871CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0871CLV-F(E)) | SPR, Inhib, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0886CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0886CLV-F(E)) | ELISA, WB | Humanized Fab |
| TAB-0887CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0887CLV-F(E)) | ELISA, WB | Humanized Fab |
| TAB-0888CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0888CLV-F(E)) | ELISA, WB | Humanized Fab |
| TAB-0889CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0889CLV-F(E)) | ELISA, WB | Humanized Fab |
| TAB-0890CLV-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0890CLV-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0894CLV-F(E) | Mouse Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0894CLV-F(E)) | ELISA, WB | Mouse Fab |
| TAB-0895CLV-F(E) | Mouse Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0895CLV-F(E)) | ELISA, WB | Mouse Fab |
| TAB-0896CLV-F(E) | Mouse Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0896CLV-F(E)) | ELISA, WB | Mouse Fab |
| TAB-0897CLV-F(E) | Mouse Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0897CLV-F(E)) | ELISA, WB | Mouse Fab |
| TAB-0894CLV-S(P) | Mouse Anti-ANGPT2 Recombinant Antibody; scFv Fragment (TAB-0894CLV-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0616MZ | Mouse Anti-ANGPT2 Recombinant Antibody (clone OTI3H7) | WB | Mouse IgG1 |
| HPAB-0111CQ | Human Anti-ANGPT2 Recombinant Antibody (HPAB-0111CQ) | ELISA, Neut, WB | Human IgG1, κ |
| HPAB-0112CQ | Human Anti-ANGPT2 Recombinant Antibody (HPAB-0112CQ) | ELISA, Neut, WB | Human IgG1, λ |
| HPAB-S0188-YC | Human Anti-ANGPT2 Recombinant Antibody (clone CrossFab) | SPR | Human IgG |
| HPAB-S0189-YC | Human Anti-ANGPT2 Recombinant Antibody (clone Fab) | SPR | Hmuan IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0170 | Hi-Affi™ Rabbit Anti-ANGPT2 Recombinant Antibody (clone DS170AB) | IHC-Fr, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-461CQ | Afuco™ Anti-ANGPT2 Recombinant Antibody (AFC-TAB-461CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0172-WJ-S(P) | Mouse Anti-ANGPT2 Recombinant Antibody (clone 10D6); scFv Fragment | ELISA | Mouse scFv |
| HPAB-AP234-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP234-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP235-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP235-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP236-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP236-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP237-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP237-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY12 | AbPlus™ Anti-ANGPT2 Magnetic Beads (VS-0424-XY12) | IP, Protein Purification | |
| VS-0724-YC1209 | AbPlus™ Anti-ANGPT2 Magnetic Beads (VS-0724-YC1209) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY79 | Human Anti-ANGPT2 (clone MEDI1/5) scFv-Fc Chimera | ELISA, Inhib, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY367 | Anti-ANGPT2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY368 | Anti-Mouse ANGPT2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY369 | Anti-Rat ANGPT2 Immunohistochemistry Kit | IHC |
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