Mouse Anti-Anti-HIV-1 antibody VRC01 Anti-idiotype Antibody (clone iv8); Fab Fragment
CAT#: PABJ-0191-F(E)
This product is a Mouse antibody Fab fragment that recognizes Human Anti-HIV-1 antibody VRC01. In addition to germline VRC01, iv8 binds other germline VRC01-class monoclonal antibodies, including NIH45-46, 3BNC60, 12A21, and VRC-CH31.
Specifications
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human Anti-HIV-1 antibody VRC01
- Species Reactivity
- Human
- Clone
- iv8
- Applications
- ELISA, Vaccine, FuncS
Product Property
- Purification
- Purified
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Vaccine, Functional Assay.
Target
- Alternative Names
- Anti-HIV-1 antibody VRC01; VRC01; Anti-HIV-1 VRC01; Anti-HIV-1 antibody; NIH45-46; 3BNC60; 12A21; VRC-CH31
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Crucial for VRC01 Class Studies
This anti-idiotype Fab fragment (clone iv8) has been an essential tool for our research into VRC01-class antibodies. It binds not just to germline VRC01 but also to related antibodies like NIH45-46 and 3BNC60. This broad recognition capability allows us to map the immune response more comprehensively in our ELISA assays.
High Purity Fab Fragment
We needed a high-quality Fab fragment for our vaccine research functional assays, and this product delivered. The purity, determined by SDS-PAGE and HPLC, was excellent (>95%). It performed reliably in our experiments designed to target the CD4 binding site interactions, acting as a perfect anti-idiotype reagent for our specific setup.
Q&As
-
Does this antibody bind only to the germline VRC01 antibody?
A: No, in addition to germline VRC01, this Mouse Anti-Anti-HIV-1 antibody (clone iv8) also binds to other germline VRC01-class monoclonal antibodies. This includes NIH45-46, 3BNC60, 12A21, and VRC-CH31. It is an anti-idiotype Fab fragment useful for studying broad neutralizing antibodies that contact the CD4 binding site.
-
What is the format and purity of this antibody?
A: This product is a Mouse antibody Fab fragment. It has been purified to a high degree, with greater than 95% purity as determined by SDS-PAGE and HPLC analysis. It is suitable for applications such as ELISA, Vaccine research, and Functional Assays (FuncS). It should be stored at -20°C for long-term stability.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone iv8"
- CAT
- Product Name
See other products for "Anti-HIV-1 antibody VRC01"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0191 | Mouse Anti-Anti-HIV-1 antibody VRC01 Anti-idiotype Antibody (clone iv8) | ELISA, Vaccine, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0191-S(P) | Mouse Anti-Anti-HIV-1 antibody VRC01 Anti-idiotype Antibody (clone iv8); scFv Fragment | ELISA, Vaccine, FuncS | Mouse scFv |
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