Recombinant chicken monoclonal antibody specially binds to human ANXA11 (annexin XI). This anti-ANXA11 antibody A5A3 can be potentially used in the treatment of Rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, poly-myositis and Raynaud's Phenomenon.
Figure 1 ANXA11 expression in GC samples and cell lines.
Expression of ANXA11 protein in primary GC tissues.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
Figure 2 Expression of ANXA11 was detected by immunohistochemistry in gastric cancer tissues.
Protein expression level of ANXA11 in GC cell lines.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
Figure 3 ANXA11 downregulation inhibits GC cell lines proliferation and clone formation.
ANXA11 downregulation causes cell cycle arrest.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
Figure 4 Down-regulation of ANXA11 in AGS and SGC-7901 cell lines led to significant cell accumulation in the G0/G1 phase.
ANXA11 downregulation causes cell cycle arrest at the G0/G1 phase.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2524z | Mouse Anti-ANXA11 Recombinant Antibody (clone 1C8) | WB, FC, ICC, IF | Mouse IgG1 |
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