Chicken Anti-ANXA11 Recombinant Antibody (clone A5A3) (CAT#: FAMAB-0001JF)
Recombinant chicken monoclonal antibody specially binds to human ANXA11 (annexin XI). This anti-ANXA11 antibody A5A3 can be potentially used in the treatment of Rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, poly-myositis and Raynaud's Phenomenon.
Specific Inquiry
WB
Figure 1 ANXA11 expression in GC samples and cell lines.
Expression of ANXA11 protein in primary GC tissues.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
IHC
Figure 2 Expression of ANXA11 was detected by immunohistochemistry in gastric cancer tissues.
Protein expression level of ANXA11 in GC cell lines.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
Inhib
Figure 3 ANXA11 downregulation inhibits GC cell lines proliferation and clone formation.
ANXA11 downregulation causes cell cycle arrest.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
FC
Figure 4 Down-regulation of ANXA11 in AGS and SGC-7901 cell lines led to significant cell accumulation in the G0/G1 phase.
ANXA11 downregulation causes cell cycle arrest at the G0/G1 phase.
Hua, K., Li, Y., Zhao, Q., Fan, L., Tan, B., & Gu, J. (2018). Downregulation of annexin A11 (ANXA11) inhibits cell proliferation, invasion, and migration via the AKT/GSK-3β pathway in gastric cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 149.
ELISA
Figure 5 Chicken sera before immunization (pre-immune) and after the final immunization (immune) were analysed for reactivity with the individual antigens in ELISA.
Pre-immune and immune sera of chickens 1 and 2 were tested for reactivity with annexin XI.
Hof, D., Hoeke, M. O., & Raats, J. M. H. (2008). Multiple‐antigen immunization of chickens facilitates the generation of recombinant antibodies to autoantigens. Clinical & Experimental Immunology, 151(2), 367-377.
Specifications
- Immunogen
- Antigen mixture 1 (annexin XI, centromere protein B, DNA topoisomerase I, histidyl tRNA synthetase, Ro60, Rpp38 and U1A) and mixture 2 (a-fodrin, human Pop1 protein, heat shock protein B3, Ro52, Rpp30, Rrp4 and Rrp42)
- Host Species
- Chicken
- Derivation
- Chicken phage display scFv library
- Specificity
- Human annexin XI
- Species Reactivity
- Human
- Clone
- A5A3
- Applications
- WB, ELISA, Inhib, IHC, FC
- Related Disease
- Rheumatoid arthritis, Systemic lupus erythematosus, Sjögren's syndrome, Systemic sclerosis, Poly-myositis, Raynaud's Phenomenon
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The ANXA11 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Inhibition, Flow Cytometry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2524z | Mouse Anti-ANXA11 Recombinant Antibody (clone 1C8) | WB, FC, ICC, IF | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0001JF-F(E) | Chicken Anti-ANXA11 Recombinant Antibody (clone A5A3); Fab Fragment | IB, WB, ELISA, FuncS | Chicken Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0001JF-S(P) | Chicken Anti-ANXA11 Recombinant Antibody (clone A5A3); scFv Fragment | IB, WB, ELISA, FuncS | Chicken scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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