Afuco™ Anti-APCS ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019ML) (CAT#: AFC-TAB-019ML)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to APCS. It is a human monoclonal antibody that can be potentially used in the treatment of AL amyloidosis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/ihc_selected.jpg
Figure 2 IHC staining of human soft tissue
(Immunohistochemical staining of human soft tissue shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7817/ihc_selected.jpg
(Immunohistochemical staining of human soft tissue shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7817/ihc_selected.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_8_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_7_5.jpg
(Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_7_5.jpg
Figure 5 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_6_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_6_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132703-APCS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132703-APCS
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Specificity
- Human APCS
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- Generic Name
- Dezamizumab
- Related Disease
- AL amyloidosis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Amyloid P component, serum; "9.5S alpha-1-glycoprotein"; MGC88159; "pentraxin-2"; "pentraxin-related"; PTX2; SAP
- Gene ID
- 325
- UniProt ID
- P02743
Related Resources
Please refer to Dezamizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Dezamizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Dezamizumab"
DrugMonitor™ Anti-Dezamizumab Antibody (VS-1224-YC357)Dezamizumab is a fully humanized monoclonal IgG1 anti-serum amyloid P component (SAP) antibody with potential anti-amyloid activity. The DrugMonitor™ Anti-Dezamizumab Antibody (VS-1224-YC357) is an anti-drug antibody (ADA) against Dezamizumab. This drug-based antibody is raised in mice immunized with the Dezamizumab. The anti-Dezamizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Dezamizumab in samples.
See other products for "APCS"
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IgG Antibody Products
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Humanized Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2232z | Mouse Anti-APCS Recombinant Antibody (clone 38A6) | WB, ELISA, FC, ICC, IF, IHC, IP | Mouse IgG1 |
| MOB-1834MZ | Mouse Anti-APCS Recombinant Antibody (clone IZC392-06) | ELISA, WB, sELISA | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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